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首页> 外文期刊>Infection and immunity >Endotoxin lethality and tolerance in mice: analysis with the B-lymphocyte-defective CBA/N strain.
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Endotoxin lethality and tolerance in mice: analysis with the B-lymphocyte-defective CBA/N strain.

机译：小鼠的内毒素致死性和耐受性：用B淋巴细胞缺陷型CBA / N菌株进行分析。

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Immune-defective and immunologically normal F1 mice derived from the CBA/N strain were used to study the influence of anti-endotoxin antibody on the lethal effects of endotoxin. Immune-defective F1 male mice were unable to make specific responses to purified preparations of E. coli O111:B4 endotoxin, whereas their immunologically normal F1 female littermates made excellent responses. The ability to form antibody to lipopolysaccharide (LPS) in these F1 mice did not influence either their natural resistance to endotoxin challenge or the effects of pretreatment with sublethal amounts of endotoxin on subsequent challenge with higher normally lethal doses. Furthermore, transfer of sera with high titers of anti-LPS antibody to mice prior to challenge with LPS failed to protect. Thus, anti-LPS antibody does not appear to play a critical role in protection of immune-defective (CBA/N X DBA/2) F1 male mice to the lethal effects of endotoxin or to the protective effects of a single sublethal dose of endotoxin on subsequent endotoxin challenge.
机译：使用源自CBA / N株的免疫缺陷和免疫学正常的F1小鼠研究抗内毒素抗体对内毒素致死作用的影响。免疫缺陷的F1雄性小鼠无法对纯化的大肠杆菌O111：B4内毒素制剂产生特异性反应，而其免疫学正常的F1雌性同窝仔小鼠则表现出优异的反应。在这些F1小鼠中形成针对脂多糖（LPS）的抗体的能力既不影响其对内毒素攻击的天然抗性，也没有影响用低致死量的内毒素预处理对随后的更高致命剂量的攻击的影响。此外，在用LPS攻击之前，将具有高滴度的抗-LPS抗体的血清转移至小鼠无法保护。因此，抗-LPS抗体在保护免疫缺陷型（CBA / NX DBA / 2）F1雄性小鼠对内毒素的致死作用或单次致死剂量的内毒素对小鼠的保护作用中似乎没有起到关键作用。随后的内毒素攻击。

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