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Biological and Immunological Properties of Encapsulated Strains of Staphylococcus aureus from Human Sources

机译：人源金黄色葡萄球菌封装菌株的生物学和免疫学性质

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Of 875 strains of Staphylococcus aureus isolated from human source clinical specimens, 37 (4.2%) were encapsulated strains. These were all negative for clumping factor and could not be typed with bacteriophages or by serology. Twenty-one of these did not produce any hemolysins, 15 produced alpha hemolysin, 1 produced beta hemolysin, and 1 produced both beta and delta hemolysins. After one or two subcultures, 27 of the encapsulated strains converted to the compact variant form, all became positive for clumping factor, 12 became phage-typable, and 24 became sero-typable. In addition, 7 strains converted from negative to alpha hemolysin production. Comparison of phage- and sero-types did not reveal any relationships. Immunologically, mice challenged with heat-killed encapsulated strains were protected against a challenge infection with the Smith diffuse strain. Protective antibodies in rabbit anti-Smith diffuse strain antisera were removed by adsorption using the encapsulated organisms isolated in this study. The adsorbed sera no longer protected against challenge infection in mice with the Smith diffuse strain. From these results, it appears that the encapsulated strains isolated were immunologically and biologically similar to the classical Smith diffuse strain.
机译：从人源临床标本中分离出的875株金黄色葡萄球菌中，有37株（4.2％）是包囊菌株。这些对聚集因子均为阴性，不能用噬菌体或血清学分型。其中有21个未产生任何溶血素，有15个产生了α溶血素，有1个产生了β溶血素，还有1个同时产生了β和δ溶血素。一到两次传代培养后，其中27个封装菌株转化为紧凑变体形式，全部都变成聚集因子阳性，有12个变为噬菌体分型，有24个变为血清分型。此外，有7个菌株从阴性溶血素转化为α溶血素。噬菌体和血清型的比较没有发现任何关系。免疫学上，用热杀死的封装菌株攻击的小鼠受到保护，免受史密斯弥散菌株的攻击感染。使用本研究中分离的包囊生物，通过吸附去除了兔抗史密斯扩散株抗血清中的保护性抗体。吸附的血清不再能防止Smith扩散株对小鼠的攻击性感染。从这些结果看来，分离出的包囊菌株在免疫学和生物学上与经典的史密斯弥散菌株相似。

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