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首页> 外文期刊>Infection and immunity >Candidate cytomegalovirus strain for human vaccination.
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Candidate cytomegalovirus strain for human vaccination.

机译：用于人类疫苗接种的巨细胞病毒候选株。

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A strain of human cytomegalovirus called Towne was isolated in WI-38 human fibrolast cell cultures from the urine of an infected infant. It was then passaged 125 times in WI-38, including three clonings, and a pool was prepared in the same cell substrate for use as a potential live attenuated vaccine. The Towne virus has a broad antigenicity and cross-reacts with the AD-169 strain. Several markers of the Towne virus were found which differentiated it from fresh isolates. One of these was resistance of the former to trypsin. The Towne virus was tested for freedom from oncogenicity or other harmful effects in preparation for tests in humans.
机译：从感染婴儿的尿液中，在WI-38人成纤维细胞培养物中分离出一种称为Towne的人巨细胞病毒株。然后将其在WI-38中传代125次，包括三个克隆，并在同一细胞底物中制备一个库，用作潜在的减毒活疫苗。 Towne病毒具有广泛的抗原性，并与AD-169株发生交叉反应。发现了Towne病毒的几种标记，将其与新鲜分离株区分开来。其中之一是前者对胰蛋白酶的抵抗力。测试Towne病毒是否具有致癌性或其他有害作用，以准备进行人体测试。

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