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首页> 外文期刊>Infection and immunity >Immunological analysis of plasma membranes of a T-strain of mycoplasma (Ureaplasma urealyticum).
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Immunological analysis of plasma membranes of a T-strain of mycoplasma (Ureaplasma urealyticum).

机译：支原体（解脲脲原体）T株质膜的免疫学分析。

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摘要

The cell membranes of a T-strain of mycoplasma, obtained by ultrasonic disruption, were as effective as whole organisms in eliciting metabolism-inhibiting and complement-fixing antibodies. The soluble fraction separated from cell membranes by centrifugation at 35,000 X g showed a minor ability to elicit an antibody response as measured by metabolism inhibition and complement fixation tests. After a further centrifugation at 100,000 X g, the immunogenic activity of the soluble fraction was completely lost. Immunogenic determinants in mycoplasma membranes could also be demonstrated by adsorption tests; cell membranes were more effective than soluble fractions in adsorbing antibody capacity from the immune sera against whole cells. It has been shown by further experiments that cell membranes have at least two major antigenic determinants, which differ either in chemical nature or in capacity to adsorb and evoke antibodies, characterized by different serological behaviors.
机译：通过超声破坏获得的支原体T株的细胞膜在诱导代谢抑制和补体固定抗体方面与整个生物一样有效。通过代谢抑制和补体固定测试测量，通过在35,000 X g下离心从细胞膜分离的可溶性级分显示出较小的引发抗体应答的能力。在100,000 X g进一步离心后，可溶级分的免疫原性活性完全丧失。支原体膜中的免疫原性决定因素也可以通过吸附试验证明。细胞膜比可溶性部分更有效地吸收免疫血清对全细胞的抗体能力。通过进一步的实验已经表明，细胞膜具有至少两种主要的抗原决定簇，其化学性质或吸附和诱发抗体的能力不同，其特征在于血清学行为不同。

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