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首页> 外文期刊>Infection and immunity >Immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally administered killed BCG cells and BCG cell walls.
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Immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally administered killed BCG cells and BCG cell walls.

机译：豚鼠移植性肝癌的免疫疗法：病灶内施用的杀死的BCG细胞和BCG细胞壁的比较。

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Heat-killed whole BCG cells (KC) and BCG cell walls (CW) were each tested in emulsified form for their potency to cause regression of a transplanted guinea pig hepatoma. On a weight basis, KC were at least as effective as CW in causing tumor regression and elimination of microscopic lymph node metastasis, and they, as well as purified protein derivative of mycobacteria, provoked delayed cutaneous hypersensitivity reactions in animals immunized with CW or with KC. On a weight basis, KC were as active as CW in eliciting delayed cutaneous hypersensitivity in sensitized guinea pigs whether the animals were immunized with CW or with KC. In unimmunized animals the inflammatory response to intradermally administered KC was similar to that induced by CW. Because KC are easier to prepare than CW, it is suggested that whole killed BCG might be used instead of CW in clinical trials of cancer treatment requiring administration of nonliving mycobacteria.
机译：将热杀死的全BCG细胞（KC）和BCG细胞壁（CW）分别以乳化形式进行测试，以评估其是否会导致移植的豚鼠肝癌消退。以重量计，KC在引起肿瘤消退和消除微观淋巴结转移方面至少与CW一样有效，并且它们以及分枝杆菌的纯化蛋白衍生物在用CW或KC免疫的动物中引起了皮肤迟发型超敏反应。 。以重量计，无论是用CW免疫还是用KC免疫，KC在引起豚鼠致敏的皮肤超敏反应方面与CW一样活跃。在未免疫的动物中，对皮内施用的KC的炎症反应与CW诱导的炎症反应相似。由于KC比CW更容易制备，因此建议在需要使用非活性分枝杆菌的癌症治疗临床试验中，可以使用完全杀死的BCG代替CW。

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