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首页> 外文期刊>Infection and immunity >Interaction of Nocardia asteroides at different phases of growth with in vitro-maintained macrophages obtained from the lungs of normal and immunized rabbits.
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Interaction of Nocardia asteroides at different phases of growth with in vitro-maintained macrophages obtained from the lungs of normal and immunized rabbits.

机译：诺卡氏小行星在不同生长阶段与从正常和免疫兔肺部获得的体外维持的巨噬细胞的相互作用。

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摘要

The interactions of cells of Nocardia asteroides GUH-2 during different stages of growth with cultured macrophages obtained from the lungs of nonimmunized and immunized rabbits were studied. The nocardial cells from all stages grew intracellularly in "normal" alveolar macrophages; however, log-phase cells increased in numbers more rapidly than did stationary-phase cells. Macrophages obtained from the lungs of specifically immunized rabbits effectively inhibited the growth of stationary-phase cells but only temporarily retarded the growth of log-phase organisms. Specific antiserum added to the nocardial cells before incubation with presensitized macrophages caused enhanced phagocytosis and inactivation of the log-phase cells but had no effect on the fate of the stationary-phase nocardia. In addition, it was fo-nd that log-phase cells were phagocytized less effectively by normal macrophages than were the stationary-phase cells, and log-phase cells were more toxic to the macrophage monolayer. From these data we conclude that secondarily induced macrophages play a major role in host resistance to pulmonary nocardial infections, and antibody may be important for effective host resistance to the filamentous form of N. asteroides. Since the nocardia were able, with time, to overcome these effects, it appears that additional host factors (such as T-lymphocytes) must be involved in an effective host response to N. asteroides.
机译：研究了诺卡氏小行星GUH-2在不同生长阶段的细胞与从未免疫和免疫兔肺中获得的培养巨噬细胞之间的相互作用。在“正常”的肺泡巨噬细胞中，所有阶段的心肌细胞都在细胞内生长。然而，对数期细胞的数量增长比固定期细胞更快。从经特殊免疫的兔子的肺部获得的巨噬细胞可有效抑制固定相细胞的生长，但只能暂时抑制对数期生物的生长。在与预敏巨噬细胞温育之前，将特定的抗血清添加到心肌细胞中，可增强吞噬作用和对数期细胞的失活，但对静止期心肌细胞的命运没有影响。另外，发现对数期细胞被正常巨噬细胞吞噬的效率比静止期细胞低，对数期细胞对巨噬细胞单层的毒性更大。从这些数据我们得出结论，第二诱导的巨噬细胞在宿主对肺部诺卡氏菌感染的抗性中起主要作用，并且抗体可能对有效的宿主对丝状形式的小行星猪笼草的抗性很重要。由于诺卡氏菌能够随着时间的推移克服这些影响，因此看来，其他宿主因子（例如T淋巴细胞）必须参与对N.小行星的有效宿主反应。

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