In Vitro Induction of Nonspecific Resistance in Macrophages by Specifically Sensitized Lymphocytes

James L. Krahenbuhl; Jack S. Remington

首页> 外文期刊>Infection and immunity >In Vitro Induction of Nonspecific Resistance in Macrophages by Specifically Sensitized Lymphocytes

【24h】

In Vitro Induction of Nonspecific Resistance in Macrophages by Specifically Sensitized Lymphocytes

机译：巨噬细胞中非特异性抗性的体外诱导特异性淋巴细胞。

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Experiments were carried out to determine whether macrophages can be activated in vitro to resist challenge with heterologous microorganisms. Sensitized spleen cells from guinea pigs chronically infected with Toxoplasma gondii were cultured with normal guinea pig peritoneal macrophages in the presence and absence of Toxoplasma antigen. Macrophage monolayers incubated with sensitized spleen cells and antigen were markedly resistant to challenge from Listeria monocytogenes. Resistance was manifested by prolonged survival of the monolayers and rapid intracellular killing of the bacteria. Macrophages incubated with sensitized spleen cells but in the absence of antigen, as well as macrophages cultured with normal spleen cells, in the presence or absence of antigen, were rapidly destroyed. Sensitized spleen cells responded to the presence of Toxoplasma antigen by increased uptake of tritium-labeled thymidine. Supernatant fluid medium obtained from cultures of macrophages, sensitized spleen cells, and antigen contained a macrophage migration inhibitory factor(s). In addition, these supernatant fluids were capable of inducing increased resistance to Listeria in normal macrophages.

机译：进行实验以确定巨噬细胞是否可以在体外激活以抵抗异源微生物的攻击。在存在和不存在弓形虫抗原的情况下，用正常豚鼠腹膜巨噬细胞培养慢性感染弓形虫的豚鼠的敏感脾细胞。与致敏的脾细胞和抗原一起孵育的巨噬细胞单层对单核细胞增生性李斯特菌的攻击具有明显的抗性。单层的存活时间延长和细菌的快速细胞内杀伤表现出抵抗力。与致敏的脾细胞但不存在抗原一起孵育的巨噬细胞，以及在存在或不存在抗原下用正常脾细胞培养的巨噬细胞均被迅速破坏。敏感的脾细胞通过增加increased标记的胸苷的摄取来响应弓形虫抗原的存在。从巨噬细胞，致敏的脾细胞和抗原的培养物中获得的上清液介质包含巨噬细胞迁移抑制因子。此外，这些上清液能够诱导正常巨噬细胞对 Listeria 的抗性增强。 展开▼

著录项

来源
《Infection and immunity》 |1971年第4期|共7页

作者
James L. Krahenbuhl; Jack S. Remington;
展开▼

作者单位

展开▼

收录信息

原文格式 PDF

正文语种

中图分类医学免疫学;

关键词

相似文献

外文文献

中文文献

专利

1. Essential role of monocytes in the in vitro production of IL-4 and nonspecific IgE antibody by peripheral blood lymphocytes from mice sensitized s.c. once with cedar pollen. [J] . Yamamoto Y, Tashiro-Yamaji J, Sakurai K, Journal of interferon and cytokine research: The official journal of the International Society for Interferon and Cytokine Research . 2007,第12期

机译：单核细胞在由致敏的小鼠外周血淋巴细胞体外产生IL-4和非特异性IgE抗体中的重要作用。一次与雪松花粉。

2. Macrophage-Agglutinating Factor Produced In Vitro by BCG-Sensitized Lymphocytes [J] . L. F. Garcia-Moreno, Quentin N. Myrvik Infection and immunity . 1977,第3期

机译：BCG敏感性淋巴细胞体外产生的巨噬细胞凝集因子

3. Partial characterization of a factor extracted from sensitized lymphocytes that inhibits the growth of Mycobacterium tuberculosis within macrophages in vitro. [J] . R Turcotte, Y Des Ormeaux, A G Borduas Infection and immunity . 1976,第2期

机译：从致敏淋巴细胞提取的因子的部分表征，该因子在体外可抑制巨噬细胞内结核分枝杆菌的生长。

4. Induction of Micronuclei by ~(153)Sm-EDTMP in Peripheral Blood Lymphocytes in vitro [C] . Kiriam F. Suzuki, Marcia A. da Silva, Maria Ines C. C. Guimaraes, International Conference on Nuclear Data for Science and Technology . 2002

机译：体外外周血淋巴细胞中〜（153）SM-EDTMP诱导微核

5. ARYL HYDROCARBON HYDROXYLASE INDUCTION IN HUMAN LUNG TISSUE, PULMONARY MACROPHAGES, AND BLOOD LYMPHOCYTES: EFFECTS OF CIGARETTE SMOKING AND LUNG CANCER [D] . MCLEMORE, THEODORE L. -1

机译：人肺组织，肺巨噬细胞和血液淋巴细胞中的芳烃羟化酶诱导：香烟烟雾和肺癌的影响

6. In Vitro Induction of Nonspecific Resistance in Macrophages by Specifically Sensitized Lymphocytes [O] . James L. Krahenbuhl, Jack S. Remington 1971

机译：巨噬细胞中非特异性抗性的体外诱导通过特异性敏化的淋巴细胞

7. Macrophage-Agglutinating Factor Produced In Vitro by BCG-Sensitized Lymphocytes [O] . L. F. Garcia-Moreno, Quentin N. Myrvik 1977

机译：通过BCG敏化淋巴细胞体外产生的巨噬细胞凝集因子

8. Results of 2 Algal Studies, a Daphnid and Fish Study, Eye Irritation and Skin Sensitization Studies, an In Vitro Ames Assay in Salmonella and a Chromosomal Aberration Assay in Human Peripheral Blood Lymphocytes with Benzoic Acid, 2(chlorosulfonyl)-3-Methyl and Methyl Ester. [R] . 2009

机译：2种藻类研究，水蚤和鱼类研究，眼睛刺激和皮肤致敏研究的结果，沙门氏菌的体外ames测定和人类外周血淋巴细胞中的染色体畸变测定，苯甲酸，2（氯磺酰基）-3-甲基和甲基酯。

1. 体外诱导的粘蛋白抗原特异性细胞毒性T淋巴细胞抗乳腺癌的研究 [J] . 李帆 ,姬静 ,史鹏燕 . 实用癌症杂志 . 2017,第001期

2. 人类白细胞介素-2与白细胞介素-7对体外诱导抗原肽SLYNTVAT特异性T淋巴细胞的影响 [J] . 朱建蒙 . 生物技术世界 . 2016,第002期

3. 不同浓度IL-2对体外诱导肽特异性细胞毒性T淋巴细胞培养体系的影响 [J] . 李桉琪 ,祁元明 ,周哲骏 . 中国癌症杂志 . 2016,第009期

4. EBV特异性细胞毒性T淋巴细胞体外诱导培养及杀伤效果鉴定 [J] . 陈广华 ,顾斌 ,陈峰 . 中国实验血液学杂志 . 2013,第006期

5. MHC五聚体方法检测基因疫苗体外诱导的抗原特异性细胞毒T淋巴细胞 [J] . 李绵洋 ,朱平 ,王成彬 . 中华检验医学杂志 . 2010,第007期

6. EBV特异性细胞毒淋巴细胞的体外诱导和对鼻咽癌细胞的杀伤活性 [C] . 陈历排 ,黄健清 ,周同冲 . 2007亚太国际肿瘤生物学和医学学术会议暨首届解放军总医院肿瘤综合防治高峰论坛及第二届中国中青年肿瘤专家论坛 . 2007

7. 体外诱导外周血同种抗原特异性淋巴细胞凋亡的研究 [A] . 王良利 . 1999

1. 体外诱导乙型肝炎病毒特异性细胞毒性T淋巴细胞的方法 [P] . 中国专利： CN102168066A . 2011-08-31

2. 一种适用于特异性细胞毒性T淋巴细胞的特异性杀伤功能的评估方法 [P] . 中国专利： CN110358805A . 2019-10-22

3. In vitro differentiation induction of lymphocytes from stem cells with genotype after gene rearrangement [P] . 外国专利： JP5288183B2 . 2013-09-11

机译：基因重排后，从具有基因型的干细胞中体外诱导分化淋巴细胞

4. In vitro differentiation induction of lymphocytes from stem cells with genotype after gene rearrangement [P] . 外国专利： JPWO2008038579A1 . 2010-01-28

机译：基因重排后，从具有基因型的干细胞中体外诱导分化淋巴细胞

5. IN VITRO DIFFERENTIATION/INDUCTION OF LYMPHOCYTE FROM STEM CELL HAVING GENOTYPE PROVIDED AFTER GENE RECONSTITUTION [P] . 外国专利： US2011020932A1 . 2011-01-27

机译：基因重组后具有基因型的干细胞的体外分化/诱导。

相关主题

In Vitro Induction of Nonspecific Resistance in Macrophages by Specifically Sensitized Lymphocytes

摘要

著录项

相似文献

相关主题

期刊订阅