...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Role of Hemopoietic Colony-Forming Cell Responses in the Pathogenesis of Ectromelia
【24h】

Role of Hemopoietic Colony-Forming Cell Responses in the Pathogenesis of Ectromelia

机译：造血细胞集落形成细胞反应在漏虫病发病机理中的作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Intraperitoneal injection of complete Freund's adjuvant which caused an extensive cellular response in the reticuloendothelial system greatly increased the severity of infection which resulted from footpad inoculation of ectromelia virus in mice. The mortality was greatest during the proliferative phase of the cellular response, indicated by the colony-forming cell response. Exposure of colony-forming cells to virus in vitro showed that those from normal bone marrow were much less susceptible to virus than those from the bone marrow of adjuvant-treated mice and more particularly those from the spleen of adjuvant-treated mice. Severe bleeding to induce anemia and a consequent erythropoietic response did not increase the mortality from ectromelia. Previous results were interpreted on the basis of these findings and a more general application of them to the pathogenesis of poxvirus infection was discussed.
机译：腹膜内注射完整的弗氏佐剂会在网状内皮系统中引起广泛的细胞反应，从而大大增加了小鼠足垫病毒接种足底感染所引起的感染严重程度。由菌落形成细胞反应表明，在细胞反应的增殖阶段，死亡率最高。菌落形成细胞在体外暴露于病毒显示，来自正常骨髓的细胞比佐剂处理的小鼠的骨髓，特别是来自佐剂处理的小鼠的脾脏对病毒的敏感性低得多。大量出血引起的贫血和随之而来的促红细胞生成反应并未增加果皮病的死亡率。在这些发现的基础上解释了先前的结果，并讨论了它们在痘病毒感染的发病机理中的更广泛应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号