Polysaccharides of the Genus Bacillus Cross-Reactive with the Capsular Polysaccharides of Diplococcus pneumoniae Type III, Haemophilus influenzae Type b, and Neisseria meningitidis Group A

Richard L. Myerowitz; Ruth E. Gordon; John B. Robbins

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Polysaccharides of the Genus Bacillus Cross-Reactive with the Capsular Polysaccharides of Diplococcus pneumoniae Type III, Haemophilus influenzae Type b, and Neisseria meningitidis Group A

机译：芽孢杆菌属的多糖与肺炎双球菌III型，流感嗜血杆菌b型和脑膜炎奈瑟氏球菌A组的荚膜多糖发生交叉反应

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We studied 174 strains of the genus Bacillus for cross-reacting antigens to the capsular polysaccharides of groups A and C meningococcus, types I and III pneumococcus, and Haemophilus influenzae type b. Cross-reactions were detected by immunodiffusion in agarose gel by using type-specific antisera and confirmed by absorption and inhibition experiments. Of 20 Bacillus pumilis strains, six had an antigen cross-reacting with group A meningococcal polysaccharide. Other cross-reactions included one strain of B. pumilis with H. influenzae type b, one of B. cereus var. mycoides with pneumococcus type III, and one of B. alvei with both type b and SIII polysaccharides. These cross-reacting antigens are polysaccharides of vegetative cells and may be extracellular in location. Because these bacilli have antigens cross-reacting with the virulence factors of pyogenic bacteria, they may, as normal flora, be an antigenic stimulus for “natural” serum anti-capsular antibodies to the type b Haemophilus and group A meningococcus polysaccharides.

机译：我们研究了174株芽孢杆菌菌株与A和C组脑膜炎球菌，I型和III型肺炎球菌以及B型流感嗜血杆菌的荚膜多糖的交叉反应抗原。使用类型特异性抗血清通过在琼脂糖凝胶中进行免疫扩散检测交叉反应，并通过吸收和抑制实验进行确认。在20株枯草芽孢杆菌菌株中，有6株具有与A组脑膜炎球菌多糖交叉反应的抗原。其他交叉反应包括一株 B。 pumilis 和 H。 b型流感病毒， B型之一。蜡状菌 var。 mycoides 具有肺炎球菌类型III，且是 B之一。带有b型和SIII型多糖的alvei 。这些交叉反应抗原是营养细胞的多糖，并且在位置上可能在细胞外。由于这些杆菌具有与化脓性细菌的致病因子交叉反应的抗原，因此它们可能作为正常菌群，成为针对“ 血友病”和“ b”型嗜血杆菌的“天然”血清抗荚膜抗体的抗原刺激物。脑膜炎球菌多糖。 展开▼

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《Infection and immunity》 |1973年第6期|共5页

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Richard L. Myerowitz; Ruth E. Gordon; John B. Robbins;
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中图分类医学免疫学;

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1. Vaccination responses to capsular polysaccharides of Neisseria meningitidis and Haemophilus influenzae type b in two C2-deficient sisters: alternative pathway-mediated bacterial killing and evidence for a novel type of blocking IgG. [J] . Selander B, Kayhty H, Wedege E, Journal of Clinical Immunology . 2000,第2期

机译：在两个C2缺陷型姐妹中对脑膜炎奈瑟氏菌和b型流感嗜血杆菌荚膜多糖的疫苗接种反应：替代途径介导的细菌杀伤和新型阻断IgG的证据。

2. An Escherichia Coli Antigen Cross-Reactive with the Capsular Polysaccharide of Haemophilus Influenzae Type b: Occurrence Among Known Serotypes, and Immunochemical and Biologic Properties of E. Coli Antisera Toward H. Influenzae Type b [J] . J. C. Parke, John B. Robbins, John K. Whisnant, The journal of immunology . 1972,第6期

机译：与b型流感嗜血杆菌荚膜多糖发生交叉反应的大肠埃希氏大肠杆菌抗原：已知血清型的发生，以及大肠杆菌抗血清对b型流感嗜血杆菌的免疫化学和生物学特性。

3. Responses of children immunized with capsular polysaccharide of Hemophilus influenzae type b, by David H. Smith, MD, et al, Pediatrics, 1973;52:637-644; and Haemophilus influenzae type b capsular polysaccharide vaccine in children: a double-blind fie [J] . Peter CG Pediatrics: Official Publication of the American Academy of Pediatrics . 1998,第1aPta2期

机译：David H.Smith，MD，等，Pediatrics，1973; 52：637-644; David H.Smith，MD，et al。，Pediatrics，1973; 52：637-644。和儿童流感嗜血杆菌b型荚膜多糖疫苗：双盲国际剑联

4. Haemophilus influenzae Type b Conjugate Vaccine with a Synthetic Capsular Polysaccharide Antigen: Chemical View [C] . Vicente Verez Bencomo, Rene Roy, Maria C. Rodriguez, American Chemical Society . 2008

机译：Hemophilus流感B型缀合物疫苗，具有合成囊多糖抗原：化学视图

5. Development and characterization of the immune response induced by peptides and DNA constructs that mimic the capsular polysaccharide of Neisseria meningitidis serogroup C. [D] . Prinz, Deborah Marie. 2005

机译：模仿脑膜炎奈瑟氏球菌血清群C的荚膜多糖的肽和DNA构建体诱导的免疫应答的发展和表征。

6. Polysaccharides of the Genus Bacillus Cross-Reactive with the Capsular Polysaccharides of Diplococcus pneumoniae Type III Haemophilus influenzae Type b and Neisseria meningitidis Group A [O] . Richard L. Myerowitz, Ruth E. Gordon, John B. Robbins 1973

机译：芽孢杆菌属的多糖与肺炎双球菌III型流感嗜血杆菌b型和脑膜炎奈瑟氏球菌A组的荚膜多糖发生交叉反应

7. Polysaccharides of the Genus Bacillus Cross-Reactive with the Capsular Polysaccharides of Diplococcus pneumoniae Type III, Haemophilus influenzae Type b, and Neisseria meningitidis Group A [O] . Richard L. Myerowitz, Ruth E. Gordon, John B. Robbins 1973

机译：芽孢杆菌属的多糖与肺泡肺炎群型III型，嗜血杆菌型B型血管瘤型，和培条脑膜炎

8. Continuation of the Evaluation of the Immunogenicity and Characterization of the Immune Response to the Capsular Polysaccharides of Haemophilus Influenzae Type B, Escherichia Coli, and Group C Neisseria Meningitidis in Infants and Children [R] . Parke, J. C. 1981

机译：继续评估婴儿和儿童中B型流感嗜血杆菌，大肠杆菌和C组脑膜炎奈瑟菌对荚膜多糖的免疫应答的免疫原性和表征

1. A群奈瑟氏脑膜炎球菌荚膜多糖-破伤风类毒素结合疫苗的制备及其免疫原性研究 [J] . 刘方蕾 ,吴兵 ,杜琳 . 微生物学免疫学进展 . 2005,第002期

2. C群奈瑟氏脑膜炎球菌荚膜多糖-TT结合疫苗的制备及其在小鼠体内免疫原性的研究 [J] . 吴兵 ,刘方蕾 ,崔萱林 . 微生物学免疫学进展 . 2005,第003期

3. 不同酸水解酪蛋白对W135群和Y群脑膜炎奈瑟菌荚膜多糖产量的影响 [J] . 白贵杰 ,罗树权 ,沈荣 . 微生物学免疫学进展 . 2019,第003期

4. 细菌内毒素对A群C群脑膜炎奈瑟菌荚膜多糖蛋白质含量测定结果的影响 [J] . 马明霞 ,冯佳丽 ,魏振洲 . 微生物学免疫学进展 . 2019,第003期

5. 脑膜炎奈瑟菌荚膜多糖合成及相关基因的研究进展 [J] . 于飞飞(综述) ,应莲芳 ,张海红(审校) . 微生物学免疫学进展 . 2016,第004期

6. AC群脑膜炎球菌－b型流感嗜血杆菌多糖结合疫苗人群免疫学效果观察 [C] . 李亚南 ,梁丽 ,李艳萍 . 2012年中国药学大会暨第十二届中国药师周 . 2012

7. B型流感嗜血杆菌的荚膜多糖抗体水平及基因分型研究 [A] . 张文佳 . 2011

1. A群脑膜炎奈瑟氏球菌荚膜多糖缀合疫苗及制备方法 [P] . 中国专利： CN103007277A . 2013-04-03

2. 含重组菌毛蛋白的抗淋病奈瑟氏球茵或脑膜炎奈瑟氏球菌的疫苗 [P] . 中国专利： CN1245512C . 2006.03.15

3. METHOD OF CLEANING BACTERIAL CAPSULAR POLYSACCHARIDE NEISSERIA MENINGITIDIS OR HAEMOPHILUS INFLUENZAE AND METHOD FOR PREPARING VACCINE [P] . 外国专利： RU2381814C2 . 2010-02-20

机译：清洁细菌性荚膜多糖奈瑟球菌或流感嗜血杆菌的方法及疫苗的制备方法

4. Multivalent immunogenic composition comprising a conjugated capsular polysaccharide or oligosaccharide Protein vehicle and Haemophilus influenzae type B without adjuvant and 2 or more polysaccharides BActerianos able to confer protection against infection by the bacteria cells, Preparation method and use. [P] . 外国专利： CL2001001490A1 . 2002-03-01

机译：包含缀合的荚膜多糖或寡糖蛋白媒介物和不含佐剂的B型流感嗜血杆菌和2种或多种多糖Bacterianos的多价免疫原性组合物，制备方法和用途，所述Bacterianos能够提供针对细菌细胞的感染的保护作用。

5. Combination of diphtheria toxoid, tetanus toxoid, pertussis antoxin, filamentous hemagglutinin, pertactin, inactivated poliovirus type 1, type 2 and type 3 and capsular polysaccharide of haemophilus influenzae type b (Infanrix - IPV / Hib) [P] . 外国专利： LU91596I2 . 2009-10-12

机译：白喉类毒素，破伤风类毒素，百日咳毒素，丝状血凝素，百日咳杆菌素，灭活的1型，2型和3型脊髓灰质炎病毒以及b型流感嗜血杆菌荚膜多糖的结合物（Infanrix-IPV / Hib）

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Polysaccharides of the Genus Bacillus Cross-Reactive with the Capsular Polysaccharides of Diplococcus pneumoniae Type III, Haemophilus influenzae Type b, and Neisseria meningitidis Group A

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