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Influence of Sex and Age on Natural Resistance to St. Louis Encephalitis Virus Infection in Mice

机译:性别和年龄对小鼠对圣路易斯脑炎病毒感染自然抵抗力的影响

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A difference was observed in susceptibility of adult male and female mice to St. Louis encephalitis (SLE) virus as measured by the death rate after intravenous challenge. Female mice that had susceptibility similar to that of males at 2 months of age had increased resistance to SLE virus at 3 and 4 months of age. The increased resistance occurred after sexual maturity, indicating that the resistance factor possibly was related to an aging process in the female. The susceptibility of male mice remained unchanged over the 2- to 4-month period. Neither pregnancy nor castration had any effect on resistance of adult mice to St. Louis encephalitis virus.
机译:通过静脉内攻击后的死亡率来衡量,观察到成年雄性和雌性小鼠对圣路易斯脑炎(SLE)病毒的敏感性不同。雌性小鼠在2个月大时的敏感性与雄性相似,在3个月和4个月大时对SLE病毒的抵抗力增强。性成熟后抵抗力增加,表明抵抗力因子可能与女性的衰老过程有关。在2到4个月内,雄性小鼠的敏感性保持不变。妊娠和去势均未对成年小鼠对圣路易斯脑炎病毒的抗性产生任何影响。

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