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首页> 外文期刊>Infection and immunity >Inhibitory and Restorative Effects of Adenine Nucleotides on Rickettsial Adsorption and Hemolysis
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Inhibitory and Restorative Effects of Adenine Nucleotides on Rickettsial Adsorption and Hemolysis

机译：腺嘌呤核苷酸对Ri肌的吸附和溶血作用的抑制和修复作用

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摘要

The adenine nucleotides, adenosine diphosphate, adenosine triphosphate, (ATP), and the methylene-bridge analogues are inhibitors of rickettsial adsorption to and the hemolysis of sheep erythrocytes. Other nucleotides, adenosine monophosphate, cyclic adenosine monophosphate, cytosine triphosphate, and guanosine triphosphate, are without effect. Adsorption and hemolysis require the generation of energy by the rickettsiae which is usually derived from glutamate. When the generation of energy from the metabolism of glutamate is inhibited by arsenite or cyanide, the addition of ATP can supply the energy to restore hemolysis. However, in the presence of the uncouplers, ATP can not restore hemolysis. Even when functioning in a restorative role, ATP still has its inhibitory properties. These results suggest that a high-energy intermediate (X ～ I), rather than ATP itself, is the energy source. The interactions of inhibitory nucleotides suggest that these compounds share a common transport system.
机译：腺嘌呤核苷酸，二磷酸腺苷，三磷酸腺苷（ATP）和亚甲基桥类似物是剂对绵羊红细胞吸附和溶血的抑制剂。其他核苷酸，单磷酸腺苷，环状单磷酸腺苷，三磷酸胞嘧啶和三磷酸鸟苷无效。吸附和溶血需要立克次体产生能量，通常来自谷氨酸。当谷氨酸代谢产生的能量被亚砷酸盐或氰化物抑制时，添加ATP可以提供能量以恢复溶血作用。但是，在存在解偶联剂的情况下，ATP无法恢复溶血。即使发挥恢复作用，ATP仍具有抑制特性。这些结果表明，高能中间体（X〜I）是能量来源，而不是ATP本身。抑制性核苷酸的相互作用表明这些化合物共享一个共同的转运系统。

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