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首页> 外文期刊>Infection and immunity >Granulomagenic activity of serologically active glycolipids from Mycobacterium bovis BCG.
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Granulomagenic activity of serologically active glycolipids from Mycobacterium bovis BCG.

机译：来自牛分枝杆菌BCG的血清学活性糖脂的肉芽瘤活性。

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摘要

The granulomagenic properties of serologically active glycolipids A1, B2, B3, and C isolated from Mycobacterium bovis BCG were studied. Glycolipid A1, dissolved in olive and injected intradermally in guinea pigs, was able to elicit a granulomatous response that seemed to be of the nonallergic type. This granulomagenic activity was quite striking since only 2 mug was necessary to elicit the reaction. The B and C glycolipids were milder granulomagenic agents. Glycolipid A1, dissolved in olive oil and injected intraperitoneally, was toxic for mice. Mice lost weight after the injection of as little as 10 mug of A1, although not even a dose of 100 mug was lethal. Glycolipid A1 failed to immunize mice against aerogenic infection with virulent tubercle bacilli.
机译：研究了从牛分枝杆菌BCG中分离出的具有血清学活性的糖脂A1，B2，B3和C的肉芽肿特性。溶解在橄榄中并在豚鼠皮内注射的糖脂A1能够引起肉芽肿性反应，似乎是非过敏型的。由于仅需要2个杯子来引发反应，所以这种肉芽肿的活性非常惊人。 B和C糖脂是较温和的肉芽肿形成剂。溶于橄榄油并腹膜内注射的糖脂A1对小鼠有毒。注射低至10杯A1后，小鼠体重减轻，尽管即使100杯A1剂量也没有致死作用。糖脂A1未能免疫小鼠以抵抗强力结核杆菌的气源性感染。

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