Increased histamine sensitivity in mice after administration of endotoxins.

R K Bergman; J J Munoz

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Increased histamine sensitivity in mice after administration of endotoxins.

机译：给予内毒素后小鼠中组胺敏感性增加。

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CFW mice given submicrogram doses of endotoxins intravenously became highly susceptible to the lethal effects of 0.5 mg of histamine given intraperitoneally 1 to 2 h later. The histamine-sensitizing effects of the endotoxins were transitory and disappeared within 6 to 8 h. L-Epinephrine administered intravenously immediately after histamine challenge protected mice from death, but aterenol and isoproterenol were ineffective. The histamine-sensitizing effect in endotoxins was precipitated by anti-endotoxin sera with a concomitant eightfold loss in activity. However, dissociation of the immune complex in 0.25 M acetic acid fully restored histamine-sensitizing activity. The transitory nature of the hypersensitivity produced by endotoxin and the high heat resistance of the active material prove that it is different from the histamine-sensitizing effects of pertussigen.

机译：静脉内给予亚微克内毒素剂量的CFW小鼠高度敏感，在1至2小时后腹膜内给予0.5 mg组胺的致死作用。内毒素的组胺敏化作用是短暂的，在6至8小时内消失。组胺攻击后立即静脉内施用L-肾上腺素可保护小鼠免于死亡，但阿替洛尔和异丙肾上腺素无效。抗内毒素血清可促进内毒素中的组胺敏化作用，并伴有八倍的活性损失。但是，在0.25 M乙酸中免疫复合物的解离完全恢复了组胺敏化活性。内毒素引起的超敏反应的短暂性质和活性物质的高耐热性证明，它与百日咳原的组胺敏化作用不同。

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《Infection and immunity》 |1977年第1期|共6页
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R K Bergman; J J Munoz;
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中图分类医学免疫学;
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6. Increased histamine sensitivity in mice after administration of endotoxins. [O] . R K Bergman, J J Munoz 1977

机译：给予内毒素后小鼠中组胺敏感性增加。
7. Increased sensitivity to histamine induced in mice by hemophilus pertussio vaccine [O] . McLaurin Angus Winston 1954

机译：百日咳嗜血杆菌疫苗对小鼠诱导的组胺敏感性增加

Increased histamine sensitivity in mice after administration of endotoxins.

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