• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Homologous and heterologous protection of mice with group A streptococcal M protein vaccines.
【24h】

Homologous and heterologous protection of mice with group A streptococcal M protein vaccines.

机译：A组链球菌M蛋白疫苗对小鼠的同源和异源保护。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purified streptococcal M proteins precipitated with alum (APM) were used to immunize mice. A trivalent vaccine of serotypes 1, 3, and 12 protected mice against challenges by homologous live streptococci and also conferred protection against serotypes 6 and 14 but not against a strain of group B streptococci. Monovalent APM vaccines afforded homologous protection and restricted heterologous protection. The extent of heterologous protection was a function of serotype combinations and was also dose dependent. Rabbit antisera exhibiting strong opsonic activities were active in vitro and in passive mouse protection only for homologous serotypes. Mouse antisera did not passively transfer protection and were not bactericidal in vitro. It was concluded that homologous and heterologous active mouse protection was most likely a result of shared antigenic determinants of the various M proteins although protection of mice could not be measured as a function of circulating anti-M antibodies.
机译：用明矾沉淀的纯化的链球菌M蛋白（APM）用于免疫小鼠。血清型1、3和12的三价疫苗可以保护小鼠免受同源活链球菌的攻击，并且还可以保护小鼠免受血清型6和14的侵害，但不能针对B组链球菌的毒株提供保护。单价APM疫苗提供了同源保护和有限的异源保护。异源保护的程度是血清型组合的函数，并且也是剂量依赖性的。表现出强调理活性的兔抗血清在体外和仅对同源血清型具有被动保护作用。小鼠抗血清没有被动转移保护，并且在体外没有杀菌作用。得出的结论是，尽管不能通过循环抗M抗体的功能来测量小鼠的保护能力，但同源和异源的活性小鼠保护很可能是各种M蛋白的共同抗原决定簇的结果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号