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首页> 外文期刊>Infection and immunity >Abortive replication of vaccinia virus in activated rabbit macrophages.
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Abortive replication of vaccinia virus in activated rabbit macrophages.

机译：痘苗病毒在活化的兔巨噬细胞中的无复制复制。

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During the course of infection of rabbits with vaccinia virus, macrophages obtained from the peritoneal cavity develop bactericidal activity and the replication of vaccinia virus becomes restricted in these cells. The abortive replication of vaccinia virus in the activated macrophages was characterized in the present study. The virus adsorbed to and was uncoated equally well in macrophages from both normal and infected rabbits. A burst of deoxyribonucleic acid synthesis of comparable magnitude took place 3 to 6 h after infection in both normal and activated macrophages. Although the production of viral antigens, as detected by immunodiffusion and immunofluorescence, was the same in both types of cells, very few virus particles were formed in activated as compared with normal macrophages. We conclude that a block in a late step of the virus replication cycle occurred in the activated macrophages.
机译：在兔痘苗病毒感染的过程中，从腹膜腔获得的巨噬细胞具有杀菌活性，痘苗病毒的复制在这些细胞中受到限制。痘苗病毒在活化的巨噬细胞中的流产复制是本研究的特征。在正常和感染的兔子的巨噬细胞中，病毒均被吸附，并且被包被的程度相同。正常和活化的巨噬细胞在感染后3至6小时爆发了相当数量的脱氧核糖核酸合成。尽管通过免疫扩散和免疫荧光法检测到的病毒抗原的产生在两种类型的细胞中都是相同的，但与正常巨噬细胞相比，在激活状态下形成的病毒颗粒很少。我们得出的结论是，病毒复制周期后期的一个阻滞发生在活化的巨噬细胞中。

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