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首页> 外文期刊>Infection and immunity >Cell-free and cell-bound antibody in nasal secretions from infants with respiratory syncytial virus infection.
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Cell-free and cell-bound antibody in nasal secretions from infants with respiratory syncytial virus infection.

机译：患有呼吸道合胞病毒感染的婴儿鼻腔分泌物中的无细胞结合抗体。

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摘要

Twenty-two infants under 9 months of age hospitalized with bronchiolitis or pneumonia due to respiratory syncytial virus (RSV) were serially sampled to determine the pattern of secretory antibody response. Using double labeling techniques, we found several types of immunoglobulin in secretions: cell-free antibody to RSV of the immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) classes; and immunoglobulins of all three classes bound to RSV-infected cells shed from the nasal epithelium (presumably cell-bound antibody to RSV). IgA attached to RSV-infected epithelial cells was almost always detected in the first available nasal sample (day 1 or 2 of hospitalization). In contrast, cell-free anti-RSV IgA first appeared an average of 3.5 days later at a time when virus antigen was disappearing from the secretion. IgG and IgM attached to RSV-infected cells appeared more irregularly. The titer of cell-free anti-RSV IgM was often higher than that of IgA early in the illness and declined as the infection resolved. Cell-free anti-RSV IgG was usually present earlier than IgA and rose during convalescence.
机译：对22例9个月以下因呼吸道合胞病毒（RSV）住院的毛细支气管炎或肺炎住院的婴儿进行了连续采样，以确定分泌性抗体反应的方式。使用双重标记技术，我们在分泌物中发现了几种类型的免疫球蛋白：针对免疫球蛋白A（IgA），免疫球蛋白G（IgG）和免疫球蛋白M（IgM）类的RSV的无细胞抗体;和与RSV感染的细胞结合的所有三类免疫球蛋白都从鼻上皮脱落（可能是针对RSV的细胞结合抗体）。附着在RSV感染的上皮细胞上的IgA几乎总是在第一个可用的鼻腔样本中（住院的第1天或第2天）检测到。相反，无细胞的抗RSV IgA平均在3.5天后首次出现，此时病毒抗原从分泌物中消失。附着于RSV感染细胞的IgG和IgM出现更加不规则。在疾病早期，无细胞的抗RSV IgM的滴度通常高于IgA，随着感染的消退而下降。无细胞的抗RSV IgG通常早于IgA出现，并且在恢复期上升。

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