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首页> 外文期刊>Infection and immunity >Lymphocyte Transformation in Repeated Gonococcal Urethritis
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Lymphocyte Transformation in Repeated Gonococcal Urethritis

机译：反复淋球菌性尿道炎中的淋巴细胞转化

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In an attempt to ascertain whether cell-mediated hypersensitivity develops in the course of a naturally acquired gonorrhea infection, lymphocytes from men with gonococcal urethritis were cultured in vitro with a gonococcal antigen. The lymphocyte response was quantitated by a radioactive assay of deoxyribonucleic acid synthesis. Lymphocytes from subjects without gonorrhea were cultured in a similar manner to determine the specificity of the reaction. The recurrent nature of many gonococcal infections allowed a concurrent evaluation of whether the intensity of the in vitro lymphocyte response is related to the history of previous exposure to the antigen concerned. This study revealed a significantly greater lymphocyte response to the gonococcal antigen in those with gonorrhea infections than in the nongonorrhea subjects (P < 0.01). The intensity and timing of the response were also consistent with specific lymphocyte stimulation.
机译：为了确定在自然获得性淋病感染过程中是否发生了细胞介导的超敏反应，将带有淋球菌尿道炎的男性淋巴细胞与淋球菌抗原进行体外培养。通过脱氧核糖核酸合成的放射性测定来定量淋巴细胞应答。来自无淋病对象的淋巴细胞以类似方式培养以确定反应的特异性。许多淋球菌感染的复发性质允许同时评估体外淋巴细胞反应的强度是否与先前接触有关抗原的历史有关。这项研究表明，淋病感染者对淋球菌抗原的淋巴细胞反应明显高于非淋病患者（ P <0.01）。反应的强度和时机也与特异性淋巴细胞刺激一致。

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