Immunological Response of Rodents to Murine Mycoplasmas

B. C. Cole; L. Golightly-Rowland; J. R. Ward; B. B. Wiley

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Immunological Response of Rodents to Murine Mycoplasmas

机译：鼠对鼠类支原体的免疫反应

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Mycoplasma arthritidis, M. pulmonis, M. neurolyticum, and M. felis strains administered on various immunization schedules induced complement-fixing and agglutinating antibodies in rats, mice, and guinea pigs. Metabolic inhibiting (MI) antibodies against M. felis were produced by guinea pigs, mice, and rats. M. neurolyticum did not induce MI antibody in mice but induced high titers in guinea pigs and rats. M. pulmonis failed to induce MI antibody titers in mice, induced low titers in rats, and induced high titers in guinea pigs. M. arthritidis induced no or very low titers in rats and low titers in mice, but induced high MI titers in guinea pigs. A positive correlation was demonstrated between ability of the mycoplasma to induce disease and lack of MI antibody formation by its natural host. It is suggested that the apparent inability of the various animals to produce MI antibodies against their natural mycoplasmal parasites may enable the mycoplasmas to become established in their hosts. The concept of biological mimicry is brought forward to explain these observations.

机译：关节炎支原体，肺炎支原体，解神经支原体和 M。以不同的免疫方案施用的felis 菌株在大鼠，小鼠和豚鼠中诱导补体固定和凝集抗体。针对 M的代谢抑制（MI）抗体。猫是由豚鼠，小鼠和大鼠产生的。 M。 Neurolyticum 不会在小鼠中诱导MI抗体，但是在豚鼠和大鼠中诱导高滴度。 M。肺炎不能诱导小鼠MI抗体滴度，不能引起大鼠低滴度，而引起豚鼠高滴度。 M。关节炎诱导的大鼠滴度没有或很低，小鼠的滴度很低，而豚鼠的MI滴度却很高。支原体诱导疾病的能力与天然宿主缺乏MI抗体的形成之间存在正相关关系。建议各种动物明显不能产生针对其天然支原体寄生虫的MI抗体可能使支原体在其宿主中建立。提出了生物模仿的概念来解释这些观察。 展开▼

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《Infection and immunity》 |1970年第4期|共7页

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B. C. Cole; L. Golightly-Rowland; J. R. Ward; B. B. Wiley;
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中图分类医学免疫学;

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机译：鼠对鼠类支原体的免疫反应

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机译：用放射性核素鼠或人抗体，与免疫性疾病和癌症相关的单克隆或多克隆抗CD20抗体进行标记过程;用于诊断“体内”和/或“体外”的试剂，是鼠或人抗体的基础。与放射性核素有关的单克隆或多克隆抗CD20抗体;通过使用由此获得的试剂进行体外诊断和/或体内免疫学疾病和癌症的方法以及用于诊断免疫学疾病和癌症的试剂盒是该试剂的基础。

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5. Method for rendering a system immunologically compatible utilizing a nucleic acid construct, a nucleic acid construct for inhibiting or regulating the function of an immune response (Ir) gene and an immunologically compatible system containing a nucleic acid construct for inhibiting or regulating the function of an immune response (Ir) gene [P] . 外国专利： US2006122130A1 . 2006-06-08

机译：利用核酸构建体，抑制或调节免疫反应（Ir）基因的功能的核酸构建体和包含核酸构建体的免疫抑制系统的方法，所述系统具有免疫学上相容的系统，所述核酸构建体用于抑制或调节免疫功能反应（Ir）基因

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Immunological Response of Rodents to Murine Mycoplasmas

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