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Effect of Corynebacterium acnes on Interferon Production in Mice

机译:痤疮棒状杆菌对小鼠干扰素产生的影响

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Exposure to Corynebacterium acnes, the most prominent member of our normal skin flora, produces stimulation of lymphoid tissue and certain reticuloendothelial system functions, as well as the immune response. Alteration of the host response is extended by these studies to include changes in the pattern of interferon production in response to a representative group of inducing agents. Serum interferon levels induced by the injection of endotoxin in mice are enhanced, whereas interferon production after injection of Newcastle disease virus, Chikungunya virus, and polyinosinic:polycytidylic acid is depressed in animals inoculated with viable or nonviable C. acnes organisms.
机译:暴露于痤疮棒状杆菌(痤疮杆菌)是我们正常皮肤菌群中最重要的成员,可刺激淋巴组织和某些网状内皮系统功能,以及免疫反应。这些研究扩展了宿主反应的改变,以包括响应于代表性诱导剂组的干扰素产生方式的变化。通过注射内毒素诱导的小鼠血清干扰素水平提高,而注射新城疫病毒,基孔肯雅病毒和多肌苷酸:聚胞苷酸后,接种有活或无活的 C的动物体内的干扰素产生受到抑制。痤疮生物。

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