Cytophilic Macroglobulin Reactive with Bacterial Protein in Mice Immunized with Ribonucleic Acid-Protein Fractions of Virulent Salmonella typhimurium

Jeffrey M. Margolis; Nancy J. Bigley

首页> 外文期刊>Infection and immunity >Cytophilic Macroglobulin Reactive with Bacterial Protein in Mice Immunized with Ribonucleic Acid-Protein Fractions of Virulent Salmonella typhimurium

【24h】

Cytophilic Macroglobulin Reactive with Bacterial Protein in Mice Immunized with Ribonucleic Acid-Protein Fractions of Virulent Salmonella typhimurium

机译：鼠伤寒沙门氏菌核糖核酸蛋白组分免疫小鼠中的细菌蛋白与嗜酸性巨球蛋白反应。

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Cytophilic macroglobulin was eluted (by heating at 56 C for 60 min) from lymphoid cells of mice immunized with subfractions of virulent Salmonella typhimurium SR-11 or vaccinated with an attenuated strain of S. typhimurium (RIA). No such macroglobulin was present on comparable cell populations from normal or adjuvant-injected mice. Cytophilic macroglobulin was also present in the sera of immunized mice. In mice immunized with RNA and protein-containing subfractions extracted from lysates of S. typhimurium SR-11, the cytophilic macroglobulin was present by 14 days after immunization, whereas it was present by 10 days in mice injected with living attenuated S. typhimurium RIA. This macroglobulin reacts specifically with protein-rich components present in the immunogenic subfractions of the whole bacterial cells and has been demonstrated to facilitate phagocytic uptake of virulent S. typhimurium SR-11. Moreover, a similar protein material was present in broth culture media in which the salmonellae were cultivated. Greater amounts were detectable in older (4 day) cultures.

机译：从用强毒的鼠伤寒沙门氏菌 SR-11亚组分免疫或用减毒的 S株接种的小鼠的淋巴样细胞中洗脱（通过在56°C加热60分钟）嗜酸性巨球蛋白。鼠伤寒（RIA）。在正常或佐剂注射的小鼠的可比较细胞群中不存在这种巨球蛋白。嗜细胞的巨球蛋白也存在于免疫小鼠的血清中。在用RNA和从 S裂解物中提取的含蛋白质的亚组分免疫的小鼠中。在鼠伤寒沙门氏菌SR-11中，在免疫后14天存在嗜细胞巨球蛋白，而在注射了减毒活的 S的小鼠中则存在10天。鼠伤寒 RIA。该巨球蛋白与整个细菌细胞的免疫原性亚组分中存在的富含蛋白质的成分发生特异性反应，并已证明可促进吞噬吞噬有毒的 S。鼠伤寒 SR-11。此外，在培养沙门氏菌的肉汤培养基中存在类似的蛋白质物质。在较旧的（4天）培养物中可检测到更多的量。 展开▼

著录项

来源
《Infection and immunity》 |1972年第3期|共8页

作者
Jeffrey M. Margolis; Nancy J. Bigley;
展开▼

作者单位

展开▼

收录信息

原文格式 PDF

正文语种

中图分类医学免疫学;

关键词

相似文献

外文文献

中文文献

专利

1. Cytophilic Macroglobulin Reactive with Bacterial Protein in Mice Immunized with Ribonucleic Acid-Protein Fractions of Virulent Salmonella typhimurium [J] . Jeffrey M. Margolis, Nancy J. Bigley Infection and immunity . 1972,第3期

机译：鼠伤寒沙门氏菌核糖核酸蛋白组分免疫小鼠中的细菌蛋白与嗜酸性巨球蛋白反应。

2. Ribonucleic Acid-Protein Fractions of Virulent Salmonella typhimurium as Protective Immunogens [J] . Randall A. Smith, Nancy J. Bigley Infection and immunity . 1972,第3期

机译：鼠伤寒沙门氏菌的核糖核酸蛋白级分作为保护性免疫原。

3. Ribonucleic Acid-Protein Fractions of Virulent Salmonella typhimurium as Protective Immunogens [J] . Randall A. Smith, Nancy J. Bigley Infection and immunity . 1972,第3期

机译：鼠伤寒沙门氏菌的核糖核酸蛋白级分作为保护性免疫原。

4. Novel Bacterial Delivery System with Attenuated Salmonella typhimurium Carrying Plasmid Encoding Mtb Antigen 85A for Mucosal Immunization Establishment of Proof of Principle in TB Mouse Model [C] . SHREEMANTA K. PARIDA, KRIS HUYGEN, BERNHARD RYFFEL, International Conference on Natural Products and Molecular Medicine . 2005

机译：新型细菌输送系统，具有减毒沙门氏菌培养质粒编码MTB抗原85A，用于粘膜免疫，在TB小鼠模型中的原理证明

5. Mucosal immunization of mice with a recombinant Salmonella choleraesuis that expresses a multimeric gonadotropin releasing hormone fusion protein. [D] . Kemp, Jeffrey M. 2011

机译：表达重组体促性腺激素释放激素融合蛋白的重组霍乱沙门氏菌对小鼠进行粘膜免疫。

6. Cytophilic Macroglobulin Reactive with Bacterial Protein in Mice Immunized with Ribonucleic Acid-Protein Fractions of Virulent Salmonella typhimurium [O] . Jeffrey M. Margolis, Nancy J. Bigley 1972

机译：鼠伤寒沙门氏菌核糖核酸蛋白组分免疫小鼠中的细菌蛋白与嗜酸性巨球蛋白反应。

7. Ribonucleic Acid-Protein Fractions of Virulent Salmonella typhimurium as Protective Immunogens [O] . 1972

机译：毒核酸蛋白分数是毒性沙门氏菌毛孢菌作为防护免疫原

8. Differential Sensitivity of Inbred Mice to Salmonella typhimurium: A Model for Genetic Regulation of Innate Resistance to Bacterial Infection [R] . O'Brien, A. D., Rosenstreich, D. L., Metcalf, E. S., 1980

机译：近交系小鼠对鼠伤寒沙门氏菌的差异敏感性：一种基因调控先天性细菌感染的模型

1. 鼠伤寒沙门氏菌鞭毛蛋白可增强DnaJ蛋白的免疫反应 [J] . 严明 ,刘宇思 ,张帅 . 中国免疫学杂志 . 2014,第008期

2. 鼠伤寒沙门氏菌外膜蛋白诱导BALB／C小鼠免疫保护的实验研究 [J] . 赵跃武 ,赵凤兰 . 微生物学通报 . 1996,第006期

3. β-溶血性链球菌、结核分支杆菌提取物与银屑病患者血清发生免疫反应蛋白组分的研究 [J] . 陈小红 ,吴勤学 ,刘训荃 . 皮肤性病诊疗学杂志 . 2005,第002期

4. 血清嗜酸性粒细胞阳离子蛋白、嗜酸性粒细胞、免疫球蛋白E及MP-IgM检测在肺炎患者病情监测中的应用分析 [J] . 张浩 ,卢滨 ,贾金广 . 实用医院临床杂志 . 2020,第001期

5. 去感热口服液在急性感染性荨麻疹治疗中的临床疗效、安全性及对血清嗜酸性粒细胞阳离子蛋白、总免疫球蛋白E及分泌型免疫球蛋白E因子影响分析 [J] . 丛林 ,马志跃 ,周子力 . 世界临床药物 . 2020,第005期

6. 鼠伤寒沙门氏菌1型菌毛介导细菌对小鼠树突状细胞的粘附及侵袭研究 [C] . 郭爱珍 ,Dieter M.Schifferli . 中国畜牧兽医学会家畜传染病分会第十次学术研讨会 . 2003

7. 鼠伤寒沙门氏菌Ⅰ型菌毛对细菌及其所携带抗原GFP诱导小鼠免疫反应的影响研究 [A] . 涂玲玲 . 2009

1. 包含一种或多种肺炎链球菌荚膜糖缀合物和含有来自流感嗜血杆菌的蛋白E和/或PilA的蛋白组分的免疫原性组合物 [P] . 中国专利： CN104968366B . 2017.12.01

2. 包含一种或多种肺炎链球菌荚膜糖缀合物和含有来自流感嗜血杆菌的蛋白E和/或PilA的蛋白组分的免疫原性组合物 [P] . 中国专利： CN104968366A . 2015-10-07

3. typhimurium Salmonella enterica serotype 1.2 having cross reactivity with Salmonella enterica serotype 4,5,12: a specific monoclonal antibody against antigen h i: - producing cell line and its use. [P] . 外国专利： ES2349204B1 . 2011-11-15

机译：鼠伤寒沙门氏菌血清型1.2与肠炎沙门氏菌血清型4,5,12具有交叉反应性：一种针对产生抗原的细胞株的特异性单克隆抗体及其用途。

4. A monoclonal antibody specific to antigen h: 1,2 of salmonella enterica serotype typhimurium that presents cross reactivity with salmonella enterica serthype 4,5,12: i: -, cellular line producer, and its use. (Machine-translation by Google Translate, not legally binding) [P] . 外国专利： ES2349204A1 . 2010-12-29

机译：对肠沙门氏菌血清型鼠伤寒沙门氏菌抗原h：1,2具有特异性的单克隆抗体，可与沙门氏菌肠型4,5,12：i：-交叉反应，细胞系生产商及其用途。（通过Google翻译进行机器翻译，没有法律约束力）

5. STRAIN OF BACTERIUM SALMONELLA TYPHIMURIUM T-10 BMC160 FOR IMMUNIZATION AGAINST HUMAN IMMUNODEFICIENCY VIRUS [P] . 外国专利： RU2192886C1 . 2002-11-20

机译：鼠伤寒沙门氏菌T-10 BMC160菌株对人免疫缺陷病毒的免疫接种

相关主题

Cytophilic Macroglobulin Reactive with Bacterial Protein in Mice Immunized with Ribonucleic Acid-Protein Fractions of Virulent Salmonella typhimurium

摘要

著录项

相似文献

相关主题

期刊订阅