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首页> 外文期刊>Infection and immunity >Reactivity of Envelope, Capsid, and Soluble Antigens of Herpesvirus hominis Types 1 and 2 in the Indirect Hemagglutination Test
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Reactivity of Envelope, Capsid, and Soluble Antigens of Herpesvirus hominis Types 1 and 2 in the Indirect Hemagglutination Test

机译：间接血凝试验中1型和2型人疱疹病毒的包膜，衣壳和可溶性抗原的反应性

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摘要

Envelope, capsid, and soluble antigens of Herpesvirus hominis (HVH) types 1 and 2 were compared to crude antigens (disrupted HVH-infected cells) for potency, type-specificity, and diagnostic value in the indirect hemagglutination (IHA) test. The envelope appeared to be the predominant component reacting in the IHA test, but recurrent HVH infections increased the reactivity of human sera with capsid antigens. The soluble antigens reacted in the IHA test with HVH immune animal sera, but very few convalescent-phase human sera showed reactivity with soluble antigens. Overall, none of the subunit antigens showed greater type-specificity than did crude antigens in IHA tests with immune animal or convalescent-phase human sera. Recurrent infections with type 1 or type 2 viruses tended to broaden heterotypic reactivity of the patients' sera with both crude and subunit antigens, even in patients showing only a single type of antibody by IHA inhibition. Subunit antigens were no more sensitive than crude antigens in demonstrating significant IHA antibody titer rises for serodiagnosis of herpesvirus infections, and they generally had to be used at lower working dilutions than crude antigens.
机译：将人疱疹病毒人疱疹病毒（HVH）1型和2型的包膜，衣壳和可溶性抗原与粗抗原（破坏的HVH感染细胞）进行比较，以了解间接血凝的效力，类型特异性和诊断价值（IHA）测试。包膜似乎是IHA测试中反应的主要成分，但是HVH反复感染增加了人血清与衣壳抗原的反应性。可溶抗原在IHA测试中与HVH免疫动物血清反应，但很少恢复期人血清显示可溶抗原的反应性。总体而言，在免疫动物或恢复期人类血清的IHA测试中，没有任何一种亚单位抗原比粗抗原具有更高的类型特异性。反复感染1型或2型病毒往往会加宽患者血清与粗抗原和亚基抗原的异型反应性，即使在通过IHA抑制仅显示单一抗体类型的患者中也是如此。亚单位抗原对血清疱疹病毒感染的血清学诊断显示出明显的IHA抗体滴度升高时，不比粗抗原更敏感，并且它们通常必须以比粗抗原更低的工作稀释度使用。

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