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首页> 外文期刊>Infection and immunity >Effects of bile and gastrointestinal secretions on the infectivity of Newcastle disease virus.
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Effects of bile and gastrointestinal secretions on the infectivity of Newcastle disease virus.

机译：胆汁和胃肠道分泌物对新城疫病毒感染性的影响。

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Bile aspirated from chicken gall bladders was found to contain substances neutralizing Newcastle disease virus (NDV). Nonspecific factors were present in the bile, probably the bile acids, which caused a reduction in the infectivity of the virus. Specific anti-NDV activity was found in the bile of birds that had been vaccinated with a lentogenic strain, Ulster, and challenged with a velogenic, viscerotropic strain, California 1083. Immunoglobulins were also found in these secretions and demonstrated to include the immunoglobulin A class as well as immunoglobulin G. Variability in the neutralizing capacity of bile was found with two different plaque clones of strain 1083, indicating antigenic heterogeneity in the viral population. No difference was found between bile from uninfected birds and the bile from NDV-immune birds in their activities against influenza strain Turkey Ontario 7732, whereas activity existed against a non-viscerotropic strain of NDV, Texas GB. These findings suggest that the specific activity of the secretions was most probably due to the presence of secretory antibody. The importance of the antiviral substances present in the alimentary tract was discussed with respect to the protection of the chicken against the viscerotropic pathotype of NDV.
机译：发现从鸡胆中吸出的胆汁含有中和新城疫病毒（NDV）的物质。胆汁中存在非特异性因素，可能是胆汁酸，这导致病毒的感染性降低。在接种了高致力菌株Ulster的鸡的胆汁中发现了特定的抗NDV活性，并用加利福尼亚州1083的致速变粘力菌的家禽攻击了胆汁。在这些分泌物中还发现了免疫球蛋白，并证明包括免疫球蛋白A类在两个不同的菌株1083的噬菌斑克隆中发现了胆汁中和能力的变异，表明病毒群体中的抗原异质性。未感染禽类的胆汁和NDV免疫禽类的胆汁在抗流感菌株土耳其安大略7732的活性上没有差异，而对非内毒素型NDV株Texas GB存在活性。这些发现表明分泌物的比活性最可能是由于分泌抗体的存在。讨论了存在于消化道中的抗病毒物质对于保护鸡免受NDV内脏型感染的重要性。

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