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首页> 外文期刊>Infection and immunity >Association of Salmonella typhimurium with, and its invasion of, the ileal mucosa in mice.
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Association of Salmonella typhimurium with, and its invasion of, the ileal mucosa in mice.

机译：鼠伤寒沙门氏菌与小鼠回肠粘膜的结合及其侵袭。

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摘要

A wild-type strain of Salmonella typhimurium and three mutant rough colonial variants of the wild type were compared for their ability to become associated with and invade the ileal mucosa of germfree and specific-pathogen-free mice. The rough-mutant strains differed from the wild type in having incomplete lipopolysaccharides lacking one or more sugars in the polysaccharide moiety. The wild-type and mutant strains also differed one from the other in the types of appendages (flagella, pili) on their surfaces. Depending upon the dosage of bacteria given, all mutant strains as well as the wild type could associate with and invade the intestinal mucosa of infected gnotobiotic mice. If the infecting dosage was high enough, at least two of the mutant strains and the wild type invade the intestinal mucosa of the specific-pathogen-free animals. O antigen, flagella, or pili do not appear to be essential for the association of S. typhimurium with the mucosal surface of the mouse ileum. O antigen on the bacterial cell surface may be important, but not essential, for invasion of the ileal mucosa.
机译：比较了鼠伤寒沙门氏菌的野生型菌株和野生型的三个突变体粗糙菌落变体与无菌小鼠和无特定病原体小鼠的回肠粘膜结合并侵入回肠粘膜的能力。突变突变体菌株与野生型菌株的不同之处在于，其不完整的脂多糖在多糖部分中缺少一种或多种糖。野生型和突变菌株的表面附肢（鞭毛，菌毛）类型也彼此不同。根据给定细菌的剂量，所有突变株以及野生型都可以与感染的致病菌小鼠的肠道粘膜结合并侵入肠道。如果感染剂量足够高，则至少有两种突变株和野生型会侵入无特定病原体动物的肠粘膜。 O抗原，鞭毛或菌毛似乎对于鼠伤寒沙门氏菌与小鼠回肠粘膜表面的结合不是必需的。细菌细胞表面的O抗原对于回肠粘膜的侵袭可能很重要，但不是必需的。

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