• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Ability of temperature-sensitive mutants of the recombinant influenza S/N (H2N1) virus to induce immunity to parental (H0N1 and H2N2) viruses.
【24h】

Ability of temperature-sensitive mutants of the recombinant influenza S/N (H2N1) virus to induce immunity to parental (H0N1 and H2N2) viruses.

机译：重组流感病毒S / N（H2N1）的温度敏感突变体诱导对亲代（H0N1和H2N2）病毒的免疫能力。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The behavior in mice of two thermosensitive (ts) mutants (denoted ts217 and ts700) of the recombinant influenza virus S/N (H2N1) was studied. The parental thermoresistant (tr) virus and both of the mutants were capable of inducing protection against pneumotropic A/Singapore (H2N2) and A/WS (H0N1) challenge viruses. Immunity against the Singapore virus, with which the S/N virus shared the hemagglutinin, developed earlier than against the WS virus, with which the S/N virus shared the neuraminidase. The tr and ts217 viruses were immunologically more active than the ts700 virus. The first two viruses grew markedly better in mouse lungs than did the latter. In the course of ts217 virus replication in vivo, revertants capable of growing at 39 degrees C appeared readily. On the other hand, the ts700 virus proved to be genetically stable. These data seem to provide evidence of a linkage between the stability of the ts phenotype, reproductive capacity in mouse lungs, and immunogenicity in the viruses examined.
机译：研究了重组流感病毒S / N（H2N1）的两个热敏（ts）突变体（分别为ts217和ts700）在小鼠中的行为。亲代耐热（tr）病毒和两个突变体均能够诱导针对趋热性A /新加坡（H2N2）和A / WS（H0N1）攻击病毒的保护。针对新加坡病毒（S / N病毒共享血凝素）的免疫力要比针对WS病毒（S / N病毒共享神经氨酸酶的免疫力）早。 tr和ts217病毒的免疫活性比ts700病毒高。前两种病毒在小鼠肺部的生长明显好于后者。在体内ts217病毒复制过程中，易于在39℃下生长的回复株出现了。另一方面，ts700病毒在基因上证明是稳定的。这些数据似乎提供了ts表型的稳定性，小鼠肺部生殖能力和所检查病毒的免疫原性之间的联系的证据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号