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首页> 外文期刊>Infection and immunity >Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen.
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Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen.

机译：人体组织和肠细菌共同抗原之间的免疫原性交叉反应。

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Sterile tissues of human subjects free from infection and malignancy were assessed for an antigen that cross-reacts with the enterobacterial common antigen (ECA). Extracts of heated homogenates (HE) and ethanol-soluble (ES) fractions of liver, kidney, muscle, and heart tissues were examined for their capacities to react with ECA antibodies, as measured by hemagglutination procedures, and to elicit ECA humoral antibodies in rabbits. Both HE and ES extracts of human liver and kidney tissues specifically inhibited ECA hemagglutination. However, ES fractions of HE preparations demonstrated significantly greater inhibiton than their HE sources. In addition, both liver and kidney ES fractions primed rabbits for a rapid and specific secondary ECA humoral response to a single administration of ECA. The cross-reactivity noted between human tissue and ECA cannot be attributed to indigenous microorganisms present in the tissues, as subcultures of tissue homogenates were always sterile. Moreover, preliminary experiments with human fetal subjects, devoid of microbial flora, yielded similar results.
机译：评估没有感染和恶性肿瘤的人类受试者的无菌组织中与肠细菌共同抗原（ECA）交叉反应的抗原。检测肝，肾，肌肉和心脏组织的加热匀浆（HE）和乙醇可溶物（ES）馏分的提取物是否与ECA抗体反应（通过血凝程序测定）和引起兔ECA体液抗体的能力。人肝和肾组织的HE和ES提取物均特异性抑制ECA血凝。但是，HE制剂的ES组分显示出比其HE来源明显更大的抑制作用。另外，肝脏和肾脏的ES级分均引发了兔子对单次ECA快速而特异性的继发性ECA体液反应的反应。由于组织匀浆的继代培养物总是无菌的，因此人类组织与ECA之间的交叉反应性不能归因于组织中存在的本地微生物。此外，对没有微生物菌群的人类胎儿受试者进行的初步实验得出了相似的结果。

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