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Protective Effect of Vaccines on Mycoplasma pulmonis-Induced Respiratory Disease of Mice

机译：疫苗对肺炎支原体引起的小鼠呼吸系统疾病的保护作用

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Mice inoculated intranasally with either a virulent or an avirulent strain of live Mycoplasma pulmonis were resistant to respiratory disease induced by a subsequent intranasal challenge with virulent organisms. Similarly, mice inoculated intravenously with the virulent strain were resistant to intranasal challenge with the same strain. In contrast, mice inoculated intravenously with avirulent M. pulmonis were not resistant to intranasal challenge with the virulent mycoplasma strain. Studies on mice inoculated intravenously with the two strains of M. pulmonis indicated that persistance of mycoplasmas in the respiratory tract may be important in inducing resistance to intranasal challenge with M. pulmonis. These observations, together with the lack of correlation between the level of serum antibodies and resistance to M. pulmonis-induced respiratory disease, suggested that local immune mechanisms were important in resistance. It is proposed that an effective vaccination schedule to protect mice against M. pulmonis-induced respiratory disease may be one that stimulates both systemic and local immune defenses. This suggestion is supported by the observation that systemic followed by local administration of inactivated M. pulmonis was more effective in inducing resistance in mice to intranasal challenge with live organisms than was systemic administration alone. In addition, mice inoculated solely by the intranasal route with inactivated mycoplasmas were resistant to M. pulmonis-induced respiratory disease. These studies indicate the importance of local defense mechanisms in the induction of resistance to M. pulmonis-induced respiratory disease in mice.
机译：鼻内接种有毒性或无毒力的肺炎支原体菌株的小鼠对随后由鼻内感染有毒生物引起的呼吸道疾病具有抵抗力。类似地，用强毒株静脉内接种的小鼠对同一株鼻内攻击具有抗性。相反，小鼠静脉注射无毒的M。肺炎支原体不能抵抗鼻内攻击。两种 M菌株静脉内接种小鼠的研究。肺炎表明，呼吸道支原体的持续存在可能对诱导 M对鼻内攻击的抵抗具有重要作用。这些观察结果以及血清抗体水平与对 M的耐药性之间缺乏相关性。肺炎引起的呼吸系统疾病表明局部免疫机制在抵抗中很重要。提出了一种有效的疫苗接种方案，以保护小鼠免于 M。肺炎引起的呼吸道疾病可能是刺激全身和局部免疫防御的一种疾病。观察发现，全身注射灭活的 M后再进行全身观察，可以支持该建议。肺炎比单独全身给药更有效地诱导小鼠抵抗活体鼻内攻击。另外，仅通过鼻内途径接种灭活的支原体的小鼠对 M具有抗性。肺炎引起的呼吸系统疾病。这些研究表明了局部防御机制在诱导对 M的抗性中的重要性。肺炎引起的小鼠呼吸系统疾病。

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