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首页> 外文期刊>Infection and immunity >Periodontal bone loss and immune response to ovalbumin in germfree rats fed antigen-free diet with ovalbumin.
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Periodontal bone loss and immune response to ovalbumin in germfree rats fed antigen-free diet with ovalbumin.

机译：在无抗原饮食中添加卵白蛋白的无菌大鼠中，牙周骨丢失和对卵白蛋白的免疫反应。

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摘要

A technique for the characterization of rat gingival lymphocytes has been described. The technique was used to obtain gingival cells from rats maintained on antigen-free diets or such diets with ovalbumin (OVA) added. Increases in gingival lymphocyte numbers in the antigen-fed (AF) animals occurred by 16 to 23 days of OVA feeding. The elevated gingival lymphocyte numbers were predominantly T lymphocytes at the initial intervals of the experiment (to 59 days of OVA feeding). At 128 days of OVA feeding T-lymphocyte numbers diminished but B-lymphocyte numbers increased, and AF animals had more than six times as many gingival B lymphocytes as animals not fed antigen. Also, AF animals showed immunoglobulin A antibody in intestinal perfusates (after 9 days of OVA feeding) and in saliva (within 23 days of OVA initiation). Plasma immunoglobulin G antibodies were not detected until 59 days of feeding. Spleen cells from AF rats showed in vitro blastogenic responses to OVA at 23 to 59 days of feeding. Periodontal bone loss was greater in AF animals after 59 and 128 days of OVA. Germfree animals fed only one antigen experienced more periodontal bone loss than animals fed the same diet not containing antigen. Therefore, immune phenomena can contribute to experimental bone loss in germfree rats.
机译：已经描述了表征大鼠牙龈淋巴细胞的技术。该技术用于从维持无抗原饮食或添加卵清蛋白（OVA）的饮食中的大鼠获得牙龈细胞。 OVA喂养16至23天后，抗原喂养（AF）动物的牙龈淋巴细胞数量增加。在实验的初始间隔（至卵入卵至59天），牙龈淋巴细胞数量的增加主要是T淋巴细胞。在OVA喂养128天时，T淋巴细胞数量减少，但B淋巴细胞数量增加，并且AF动物的牙龈B淋巴细胞的数量是未喂养抗原的动物的六倍以上。此外，AF动物在肠灌注液（OVA喂养9天后）和唾液（OVA起始23天之内）也显示出免疫球蛋白A抗体。直到喂食59天才检测到血浆免疫球蛋白G抗体。在进食后23至59天，来自AF大鼠的脾细胞显示出对OVA的体外成胚反应。在OVA接种59天和128天后，AF动物的牙周骨损失更大。仅饲喂一种抗原的无胚动物比饲喂相同饮食但不含抗原的动物的牙周骨损失更多。因此，免疫现象可导致无菌大鼠的实验性骨丢失。

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