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首页> 外文期刊>Infection and immunity >Correlates to Increased Lethality of Attenuated Venezuelan Encephalitis Virus Vaccine for Immunosuppressed Hamsters
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Correlates to Increased Lethality of Attenuated Venezuelan Encephalitis Virus Vaccine for Immunosuppressed Hamsters

机译：与委内瑞拉脑炎病毒减毒疫苗的免疫抑制仓鼠致死率增加相关

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Splenectomy or pretreatment of adult hamsters with cyclophosphamide (Cytoxan) increased the lethality of the TC-83 vaccine strain of Venezuelan encephalitis virus (VEE), inoculated subcutaneously, from 12% for normal hamsters to 75 and 76%, respectively. Neither splenectomy nor cyclophosphamide treatment significantly increased the lethality of Pixuna virus. Cytoxantreated (Cy) hamsters developed and maintained levels of TC-83 virus higher than normal infected controls in blood, brain, spleen, and femoral bone marrow; splenectomy had a similar but less intense effect. A severe myeloid necrosis of femoral bone marrow developed 4 to 9 days after TC-83 virus inoculation in 78% of the Cy hamsters and in 48% of the splenectomized (Sx) hamsters. In contrast, only 13% of normal TC-83-infected hamsters developed this lesion. Extensive hemorrhagic lesions in the olfactory lobes and adjacent areas of the brain also developed more frequently in Cy or Sx hamsters than in normal infected controls. Lethally infected hamsters developed and maintained a severe thrombocytopenia, which may be related to the bone marrow lesion and to the hemorrhagic manifestations of lethal VEE infections.
机译：脾切除术或用环磷酰胺（Cytoxan）预处理成年仓鼠可使皮下接种的委内瑞拉脑炎病毒（VEE）TC-83疫苗株的致死率从正常仓鼠的12％分别增至75％和76％。脾切除术和环磷酰胺治疗均未显着增加Pixuna病毒的致死性。 Cytoxanan（Cy）仓鼠在血液，大脑，脾脏和股骨骨髓中形成并维持的TC-83病毒水平高于正常感染对照组。脾切除术具有相似但强度较小的效果。 TC-83病毒接种后4至9天，在78％的Cy仓鼠和48％的脾切除的（Sx）仓鼠中发生了股骨髓的严重髓样坏死。相反，只有TC-83感染的正常仓鼠中有13％发生了这种病变。与正常感染的对照组相比，Cy或Sx仓鼠嗅觉叶和大脑邻近区域的出血性病变也更频繁。受到致命感染的仓鼠会发展并维持严重的血小板减少症，这可能与骨髓病变和致命VEE感染的出血表现有关。

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