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首页> 外文期刊>Infection and immunity >Antibody-mediated elimination of malaria parasites (plasmodium berghei) in vivo.
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Antibody-mediated elimination of malaria parasites (plasmodium berghei) in vivo.

机译：在体内抗体介导的疟疾寄生虫（伯氏疟原虫）的消除。

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An infective preparation of extracellular blood forms (FP) of Plasmodium berghei was used to study some aspects of the interaction between protective antibodies and malaria parasites. FP but not infected erythrocytes (IRBC) were shown by the fluorescent antibody technique to be coated by antibodies after in vitro incubation with immune serum. Preincubation of both FP and IRBC with immune serum followed by their washing did not result in enhanced elimination of the parasites in vivo. However, FP preincubated with immune serum and subsequently washed were eliminated more efficiently than FP preincubated with normal serum if the preparations were injected with some immune serum. Such an increase in the efficiency of elimination was not detected with similarly pretreated IRBC. It is thus probable that protective antibodies acted in vivo against extracellular parasites rather than against parasites in erythrocytes. The interaction between parasites and antibodies may be of a highly reversible nature, and washing of the in vitro-treated parasites may cause elution of antibody from the sensitized parasites so that the amount of antibody on the parasite falls below the critical level required for in vivo elimination.
机译：感染伯氏疟原虫的细胞外血型（FP）的感染性制剂用于研究保护性抗体与疟原虫之间相互作用的某些方面。荧光抗体技术显示，FP与未感染的红细胞（IRBC）在与免疫血清体外孵育后被抗体包被。 FP和IRBC与免疫血清的预温育，然后进行洗涤，并未导致体内寄生虫的消除增强。但是，如果将制剂注射一些免疫血清，则与免疫血清预孵育的FP相比与正常血清预孵育的FP效率更高。用类似的预处理IRBC未能检测到消除效率的这种提高。因此，保护​​性抗体可能在体内针对细胞外寄生虫而不是针对红细胞中的寄生虫起作用。寄生虫与抗体之间的相互作用可能具有高度可逆的性质，清洗体外处理过的寄生虫可能会导致抗体从致敏寄生虫中洗脱出来，从而使寄生虫上的抗体量降至体内所需的临界水平以下消除。

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