• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Cross-reacting herpes simplex virus antigens in hamster and mouse cells transformed by ultraviolet light-inactivated herpes simplex virus type 2.
【24h】

Cross-reacting herpes simplex virus antigens in hamster and mouse cells transformed by ultraviolet light-inactivated herpes simplex virus type 2.

机译：由紫外线灭活的2型单纯疱疹病毒转化的仓鼠和小鼠细胞中的交叉反应单纯疱疹病毒抗原。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Murine and hamster cell lines, each transformed with a different strain of herpes simplex virus (HSV), were examined for cross-reacting antigens by in vitro and in vivo assays. A comparative study by the indirect immunofluorescence technique detected common cross-reacting viral antigens. Cytoplasmic fluorescence patterns were observed in the 333-8-9 hamster line, the H238 murine line, and the H238 clonal lines; these patterns were identical to the fluorescence pattern of HSV -2-infected controls when reacted with HSV antiserum. Tumor rejection studies in the BALB/c host indicated that each cell line provided immunity against a tumorigenic challenge of transformed mouse cells. The H238 clone EC1 3 provided a 53% immunity against itself at an inoculum of 10(6); the 333-8-9 line supported a 26% immunity. These data demonstrate a common HSV antigenicity between the murine and hamster transformed lines and further indicate that the HSV genome is involved in transformation.
机译：通过体外和体内试验检查了分别用不同株的单纯疱疹病毒（HSV）转化的鼠和仓鼠细胞系的交叉反应抗原。通过间接免疫荧光技术进行的比较研究检测到了常见的交叉反应病毒抗原。在333-8-9仓鼠系，H238鼠系和H238克隆系中观察到细胞质荧光模式。当与HSV抗血清反应时，这些模式与被HSV -2-感染的对照的荧光模式相同。在BALB / c宿主中进行的肿瘤排斥研究表明，每种细胞系均具有针对转化的小鼠细胞致瘤性攻击的免疫力。 H238克隆EC1 3在10（6）的接种量下对其自身具有53％的免疫力; 333-8-9线支持26％的抗扰度。这些数据证明了鼠和仓鼠转化品系之间具有共同的HSV抗原性，并且进一步表明HSV基因组参与了转化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号