Lipid A antiserum-mediated protection against lipopolysaccharide- and lipid A-induced fever and skin necrosis.

E T Rietschel; C Galanos

首页> 外文期刊>Infection and immunity >Lipid A antiserum-mediated protection against lipopolysaccharide- and lipid A-induced fever and skin necrosis.

【24h】

Lipid A antiserum-mediated protection against lipopolysaccharide- and lipid A-induced fever and skin necrosis.

机译：脂质A抗血清介导的抗脂多糖和脂质A引起的发烧和皮肤坏死的保护作用。

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The antiendotoxic activity of lipid A antiserum was studied in rabbits, using lipid A (lipopolysaccharide)-induced fever and skin necrosis as test systems. It was found that lipid A antiserum had no significant antipyretic effect when it was incubated with lipid A or injected intravenously before lipid A challenge. However, in animals that were pretreated (day 0) with a single dose of lipid A (lipopolysaccharide), a significant protective effect of passively transferred antiserum (day 1) to lipid A (lipopolysaccharide fever) (day 2) was observed. Also, the lipid A (lipopolysaccharide)-induced local shwartzman reaction could be prevented by lipid A antiserum. In the fever system, the degree of protection depended on the preparative and the challenge doses as well as on the amount of antiserum transferred. The fever protection mediated by lipid A antiserum seemed to be lipid A (lipopolysaccharide) specific with regard to both the preparative and the challenge injections. Lipid A specificity of the protective factor present in the antiserum was indicated by the fauggest that the factor might be identical with lipid A-specific immunoglobulin. The significance of the preparative injection is not understood at the present time. Iti is concluded, however, that in the fever protection system described, besides specific humoral factors, other factors, perhaps cellular, are involved.

机译：使用脂质A（脂多糖）诱导的发烧和皮肤坏死作为测试系统，研究了兔子体内脂质A抗血清的抗内毒素活性。已经发现，当将脂质A抗血清与脂质A温育或在脂质A攻击之前静脉内注射时，其没有明显的解热作用。但是，在用单剂量脂质A（脂多糖）预处理（第0天）的动物中，观察到被动转移的抗血清（第1天）对脂质A（脂多糖热）（第2天）的显着保护作用。同样，脂质A抗血清可预防脂质A（脂多糖）诱导的局部shwartzman反应。在发烧系统中，保护程度取决于制备剂量和攻击剂量以及转移的抗血清量。就制备和挑战注射而言，由脂质A抗血清介导的发烧保护似乎是脂质A（脂多糖）特异性的。最强的迹象表明抗血清中存在的保护因子的脂类特异性，该因子可能与脂类特异性免疫球蛋白相同。目前尚不了解制备注射的重要性。结论是，在所述的发烧保护系统中，除了特定的体液因素外，还涉及其他因素，也许是细胞因素。

著录项

来源
《Infection and immunity》 |1977年第1期|共16页
作者
E T Rietschel; C Galanos;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类医学免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. Scientific Opinion on the substantiation of health claims related to Camellia sinensis (L.) Kuntze (tea), including catechins in green tea, and improvement of endothelium‐dependent vasodilation (ID 1106, 1310), maintenance of normal blood pressure (ID 1310, 2657), maintenance of normal blood glucose concentrations (ID 1108), maintenance of normal blood LDL cholesterol concentrations (ID 2640), protection of the skin from UV‐induced (including photo‐oxidative) damage (ID 1110, 1119), protection of DNA from oxidative damage (ID 1120, 1121), protection of lipids from oxidative damage (ID 1275), contribution to normal cognitive function (ID 1117, 2812), “cardiovascular system” (ID 2814), “invigoration of the body” (ID 1274, 3280), decreasing potentially pathogenic gastro‐intestinal microorganisms (ID 1118), “immune health” (ID 1273) and “mouth” (ID 2813) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [J] . EFSA Journal . 2011,第4期

机译：关于证实茶花茶（Camelelli sinensis（L.）Kuntze）（包括绿茶中的儿茶素）的健康主张的科学意见，以及改善内皮依赖性血管舒张（ID 1106，1310），维持正常血压（ID 1310， 2657），维持正常血糖浓度（ID 1108），维持正常血液LDL胆固醇浓度（ID 2640），保护皮肤免受紫外线（包括光氧化）损害（ID 1110、1119），来自氧化损伤的DNA（ID 1120、1121），保护脂质免受氧化损伤（ID 1275），对正常认知功能的贡献（ID 1117、2812），“心血管系统”（ID 2814），“机体活力”（ ID 1274、3280），根据第1924/2006号法规（EC）第13（1）条，减少潜在的致病性胃肠道微生物（ID 1118），“免疫健康”（ID 1273）和“口”（ID 2813）
2. Scientific Opinion on the substantiation of health claims related to beta carotene and protection of DNA, proteins and lipids from oxidative damage (ID 19, 197, 1262, 1460), protection of the skin from UV‐induced (including photo‐oxidative) damage (ID 178, 197, 1263, 1461, 1968, 2320) and maintenance of the normal function of the immune system (ID 200, 1462) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [J] . EFSA Journal . 2011,第4期

机译：关于证实与β胡萝卜素有关的健康主张的科学意见，以及保护DNA，蛋白质和脂质免受氧化损害（ID 19、197、1262、1460），保护皮肤免受紫外线引起的（包括光氧化）损害（ ID 178，197，1263，1461，1968，2320）和维护（EC 200，1462）的免疫系统正常功能（EC 1924/2006第13（1）条）
3. Scientific Opinion on the substantiation of health claims related to lutein and protection of DNA, proteins and lipids from oxidative damage (ID 3427), protection of the skin from UV‐induced (including photo oxidative) damage (ID 1605, 1779) and maintenance of normal vision (ID 1779, 2080) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [J] . EFSA Journal . 2011,第4期

机译：关于证实叶黄素和保护DNA，蛋白质和脂质免受氧化损害（ID 3427），保护皮肤免受UV诱导（包括光氧化）损害（ID 1605、1779）和维护皮肤健康的科学主张的科学意见符合1924/2006号法规（EC）第13（1）条的正常视力（ID 1779，2080）
4. NEW FRONTIERS OF MALDI-IMS AND LIPIDOMICS: AN UNTARGETED APPROACH TO SKIN LIPIDS MAPPING [C] . Sara Tortorella, Fang Xie, Paolo Tiberi, International Mass Spectrometry Conference . 2018

机译：Maldi-IMS和Limidomics的新领域：皮肤脂质绘图的未明确方法
5. The role of the stratum corneum lipids and enzymes in skin condition. [D] . Rogers, Julia S. 2001

机译：角质层脂质和酶在皮肤状况中的作用。
6. Lipid A antiserum-mediated protection against lipopolysaccharide- and lipid A-induced fever and skin necrosis. [O] . E T Rietschel, C Galanos 1977

机译：脂质A抗血清介导的抗脂多糖和脂质A引起的发烧和皮肤坏死的保护作用。
7. Interplay Between Membrane Lipid Peroxidation and Photoproduct Formation in the Ultraviolet A-Induced Phototoxicity of Vemurafenib in Skin Keratinocytes [O] . Ana Teixeira, Patrice Morlière, João Ferreira, 2016

机译：膜脂质过氧化与光调节在皮肤角蛋白酶细胞中vemuriafenib的紫外诱导的光调味物质之间的相互作用
8. Influence of Human Skin Surface Lipids on Protection Time of Topical Mosquito Repellent. [R] . Skinner, W. A., Tong, H. C., Johnson, H., 1977

机译：人体皮肤表面脂质对局部驱蚊剂保护时间的影响。

Lipid A antiserum-mediated protection against lipopolysaccharide- and lipid A-induced fever and skin necrosis.

摘要

著录项

相似文献

相关主题

期刊订阅