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Effect of estrogens on the myeloperoxidase-mediated antimicrobial system.

机译:雌激素对髓过氧化物酶介导的抗菌系统的影响。

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Estradiol 17 beta prevented the fall in the microbicidal activity of the myeloperoxidase-H2O2-halide system induced by high H2O2 concentrations. In contrast, when the H2O2 (and halide) concentrations were low the myeloperoxidase-H2O2-halide antimicrobial system was inhibited by estradiol. These properties of estradiol 17 beta were shared by estradiol 17 alpha, estrone, estriol, ethinyl estradiol, and phenol, but not by estradiol-3-benzoate, testosterone, progesterone, hydroxyprogesterone, cortisone, hydrocortisone, or deoxycorticosterone.
机译:雌二醇17 beta阻止了过高的H2O2浓度引起的髓过氧化物酶-H2O2-卤化物系统杀微生物活性的下降。相反,当H2O2(和卤化物)的浓度较低时,雌二醇会抑制髓过氧化物酶-H2O2-卤化物的抗菌系统。雌二醇17α,雌酮,雌三醇,乙炔基雌二醇和苯酚具有这些特性,但雌二醇-3-苯甲酸酯,睾丸激素,孕酮,羟基孕酮,可的松,氢化可的松或脱氧皮质酮不具有这些特性。

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