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首页> 外文期刊>Infection and immunity >Phagocytosis-induced injury of normal and activated alveolar macrophages.
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Phagocytosis-induced injury of normal and activated alveolar macrophages.

机译：吞噬作用引起的正常和活化肺泡巨噬细胞损伤。

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The present study tested the hypothesis that BCG-activated macrophages become injured when they phagocytose certain particulates. The data indicate that alveolar macrophages obtained from Mycobacterium bovis BCG-sensitized animals were more susceptible to cell death after in vitro incubation with BCG or zymosan than were macrophages from normal animals. Increased susceptibility was dependent on phagocytosis, since incubation with cytochalasin B, a phagocytosis inhibitor, abrogated the effect. Catalase, cytochrome c, and ascorbic acid offered partial protection to the macrophage, suggesting the involvement of free radicals in the generation of cytotoxicity. Not all of the cells from the alveolar populations were equally susceptible to cell death, thus suggesting either heterogeneity in the cell population or a requirement of more than one cell type in the induction of necrosis or both.
机译：本研究检验了BCG激活的巨噬细胞吞噬某些颗粒时受到伤害的假说。数据表明，从牛分枝杆菌BCG致敏动物中获得的肺泡巨噬细胞与卡介苗或酵母聚糖体外温育后比正常动物的巨噬细胞对细胞死亡更敏感。易感性增加取决于吞噬作用，因为与吞噬作用抑制剂细胞松弛素B孵育可消除这种作用。过氧化氢酶，细胞色素c和抗坏血酸为巨噬细胞提供了部分保护，表明自由基参与了细胞毒性的产生。并非来自肺泡群体的所有细胞都同样容易受到细胞死亡的影响，因此提示细胞群体异质性或诱导坏死需要一种以上的细胞类型，或两者兼而有之。

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