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首页> 外文期刊>Infection and immunity >Replication of vesicular stomatitis virus facilitated by Shope fibroma virus in vivo.
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Replication of vesicular stomatitis virus facilitated by Shope fibroma virus in vivo.

机译：Shope纤维瘤病毒在体内促进了水泡性口炎病毒的复制。

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Previous studies show that Shope fibroma virus facilitates replication of vesicular stomatitis virus (VSV) in some rabbit cells grown in vitro. In the present investigation, the possibility that these two viruses can also interact in vivo was determined. Rabbits inoculated intradermally with both viruses together, or each separately, were examined for the formation of lesions or tumors and for the production of infectious virus. The presence of VSV interfered with tumorigenesis by Shope fibroma virus. In tumors already formed, production of infectious VSV was greater than in normal skin. Hence, each virus affected the other. Sera and tissues of normal rabbits were found to contain a substance which inhibits VSV; this may act to limit replication of VSV in rabbit skin. In addition, cultured rabbit skin cells appeared to adsorb VSV inefficiently. When persistently infected by Shope fibroma virus, however, adsorption of VSV was markedly improved. Our results suggest that in vivo Shope fibroma virus may facilitate adsorption of VSV to reduce the effect of a natural inhibitor and consequently enhance production of infectious virus.
机译：先前的研究表明，Shope纤维瘤病毒可促进一些体外培养的兔细胞中水泡性口炎病毒（VSV）的复制。在本研究中，确定了这两种病毒也可以在体内相互作用的可能性。皮内接种了两种病毒一起或分别单独接种的兔子，检查了病变或肿瘤的形成以及感染性病毒的产生。 VSV的存在干扰了Shope纤维瘤病毒的肿瘤发生。在已经形成的肿瘤中，传染性VSV的产生大于正常皮肤。因此，每种病毒都会相互影响。发现正常兔子的血清和组织中含有一种抑制VSV的物质。这可能会限制VSV在兔皮中的复制。另外，培养的兔皮肤细胞似乎不能有效吸附VSV。但是，当被Shope纤维瘤病毒持续感染时，VSV的吸附明显改善。我们的结果表明，体内Shope纤维瘤病毒可促进VSV的吸附，从而降低天然抑制剂的作用，从而提高传染性病毒的产生。

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