Enhancement of generation of monocyte tissue thromboplastin by bacterial phagocytosis: possible pathway for fibrin formation on infected vegetations in bacterial endocarditis.

C J van Ginkel; L Th?rig; J Thompson; J I Oh; W G van Aken

首页> 外文期刊>Infection and immunity >Enhancement of generation of monocyte tissue thromboplastin by bacterial phagocytosis: possible pathway for fibrin formation on infected vegetations in bacterial endocarditis.

【24h】

Enhancement of generation of monocyte tissue thromboplastin by bacterial phagocytosis: possible pathway for fibrin formation on infected vegetations in bacterial endocarditis.

机译：细菌吞噬作用增强单核细胞组织凝血活酶的生成：细菌性心内膜炎中感染植物上血纤蛋白形成的可能途径。

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The deposition of fibrin on infected vegetations and the presence of mononuclear phagocytes that have phagocytized bacteria are remarkabe features in experimental bacterial endocarditis. In a study in vitro, we show that phagocytosis of bacteria by human monocytes enhances thromboplastin generation by these cells. Maximal enhancement of the generation of thromboplastin by monocytes was about six times compared with that in the control experiment without bacteria, and it was obtained by preincubation of the monocytes with 5 to 10 bacteria per monocyte. No quantitative difference was observed between Staphylococcus epidermidis and Streptococcus sanguis as to the enhancement of the monocyte thromboplastin generation. An enhancement of the procoagulant activity generation was also observed after addition of bacteria to human or rabbit whole blood. Probably, this generation was also due to synthesis of thromboplastin by monocytes. It is conceivable that fibrin deposition on infected vegetations during bacterial endocarditis is mediated by thromboplastin synthesis by monocytes.

机译：在实验性细菌性心内膜炎的标志性特征是纤维蛋白在被感染的植物上的沉积以及具有吞噬细胞的单核吞噬细胞的存在。在一项体外研究中，我们显示了人类单核细胞吞噬细菌会增强这些细胞的促凝血酶原生成。与没有细菌的对照实验相比，单核细胞能最大程度地增强凝血活酶的生成，这是通过将单核细胞与每只单核细胞5至10个细菌进行预孵育而获得的。表皮葡萄球菌和血链球菌之间在单核细胞促凝血酶原蛋白生成的增强方面未见定量差异。在向人或兔全血中添加细菌后，还观察到促凝血活性产生的增强。可能这一代也归因于单核细胞合成的凝血活酶。可以想象，细菌性心内膜炎期间纤维蛋白在感染植物上的沉积是由单核细胞的促凝血酶原酶合成介导的。

著录项

来源
《Infection and immunity》 |1979年第1期|共8页
作者
C J van Ginkel; L Th?rig; J Thompson; J I Oh; W G van Aken;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类医学免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. Monocytes maintain tissue factor activity after cytolysis of bacteria-infected endothelial cells in an in vitro model of bacterial endocarditis. [J] . Veltrop MH, Beekhuizen H The Journal of Infectious Diseases . 2002,第8期

机译：在细菌性心内膜炎的体外模型中，单核细胞在细菌感染的内皮细胞发生细胞溶解后保持组织因子活性。
2. Stimulation of monocyte tissue factor expression in an in vitro model of bacterial endocarditis. [J] . M J Bancsi, J Thompson, R M Bertina Infection and immunity . 1994,第12期

机译：在细菌性心内膜炎的体外模型中刺激单核细胞组织因子表达。
3. Bacterial load and defective monocyte-derived macrophage bacterial phagocytosis in biomass smoke-related COPD [J] . Ghosh Baishakhi, Gaike Akshay H., Pyasi Kanchan, The European respiratory journal : . 2019,第2期

机译：细菌负荷和缺陷的单核细胞衍生的生物质烟雾相关COPD中的巨噬细胞吞噬作用
4. Accelerated Neutral Atom Beam processing of medical devices enhances tissue integration while reducing bacterial attachment [C] . J.Khoury, B.Phok, S.Kirkpatrick TechConnect World Innovation Conference Expo;Annual SBIR/STTR Spring Innovation Conference;Annual Nanotech Conference Expo;AI TechConnect Spring Conference Expo . 2019

机译：加速的中性原子束加工在减少细菌附件的同时增强组织积分
5. Enhancement of generation of monocyte tissue thromboplastin by bacterial phagocytosis: possible pathway for fibrin formation on infected vegetations in bacterial endocarditis. [O] . C J van Ginkel, L Thörig, J Thompson, 1979

机译：细菌吞噬作用增强单核细胞组织凝血活酶的生成：细菌性心内膜炎中感染植物上血纤蛋白形成的可能途径。
6. Enhancement of generation of monocyte tissue thromboplastin by bacterial phagocytosis: possible pathway for fibrin formation on infected vegetations in bacterial endocarditis [O] . C J van Ginkel, L Thörig, J Thompson, 1979

机译：细菌吞噬作用的产生单核细胞组织癌蛋白质的产生：纤维蛋白形成的可能途径对细菌性心内膜炎的植被

Enhancement of generation of monocyte tissue thromboplastin by bacterial phagocytosis: possible pathway for fibrin formation on infected vegetations in bacterial endocarditis.

摘要

著录项

相似文献

相关主题

期刊订阅