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首页> 外文期刊>Infection and immunity >Comparative Antigenicity and Immunogenicity of A/USSR/77 Influenza Vaccines in Normal and Primed Mice
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Comparative Antigenicity and Immunogenicity of A/USSR/77 Influenza Vaccines in Normal and Primed Mice

机译：A / USSR / 77流感疫苗在正常小鼠和初免小鼠中的比较抗原性和免疫原性

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In response to the threat of wide-spread epidemics of influenza in the United States due to the A/USSR/77 strain of virus, vaccines containing A/USSR/77 virus were prepared by four manufacturers. The vaccines were standardized by immunological measurements of viral hemagglutinin and were tested for their ability to induce serum hemagglutination-inhibiting antibodies in mice and to protect the animals against challenge infection with A/USSR/77 virus. Whole-virus and subunit virus vaccines were found to be equally efficacious, in contrast to our previous findings with vaccines prepared from other influenza virus strains. The effect of priming animals by infection with representative viruses of earlier eras on their response to A/USSR/77 vaccines was also studied. Enhanced responses were noted to both subunit and whole-virus A/USSR/77 vaccines in animals primed with viruses prevalent before 1957; higher antibody titers were induced with the subunit vaccine. A high degree of heterologous protection to A/USSR/77 challenge infection was found in mice primed with virus strains having hemagglutinin antigens unlike those of A/USSR/77 virus. Comparison of the responses of mice with those of humans inoculated with the same vaccines showed a similarity in many instances, with higher responses in those individuals primed with H0N1 and H1N1 viruses than in younger vaccinees.
机译：为了应对由于A / USSR / 77病毒在美国引起的流行性感冒的广泛传播的威胁，由四家制造商制备了含有A / USSR / 77病毒的疫苗。通过对病毒血凝素的免疫学测量对疫苗进行了标准化，并测试了它们在小鼠中诱导血清血凝抑制抗体的能力，以及保护动物免受A / USSR / 77病毒攻击感染的能力。与我们先前从其他流感病毒株制备的疫苗的发现相反，发现全病毒和亚单位病毒疫苗具有同等效力。还研究了通过感染更早时期的代表性病毒引发的动物对动物对A / USSR / 77疫苗的反应的影响。在用1957年以前流行的病毒引发的动物中，对亚单位和全病毒A / USSR / 77疫苗的反应均得到增强。亚单位疫苗诱导更高的抗体滴度。与A / USSR / 77病毒不同，在用具有血凝素抗原的病毒株引发的小鼠中发现了对A / USSR / 77挑战感染的高度异源保护。在许多情况下，将小鼠的反应与接种相同疫苗的人的反应进行比较表明，在接种H0N1和H1N1病毒的个体中，其反应要比年轻的疫苗更高。

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