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首页> 外文期刊>Infection and immunity >Induction of tumor-specific cell-mediated immunity by a noninfectious type-C virus.
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Induction of tumor-specific cell-mediated immunity by a noninfectious type-C virus.

机译:非传染性C型病毒诱导肿瘤特异性细胞介导的免疫。

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Hamsters immunized with either noninfectious hamster type-C virus (D9) or irradiated D9 tumor cells were tested for cell-mediated immune reactivity by the macrophage migration inhibition assay. The migration of peritoneal exudate cells from immunized hamsters was significantly inhibited by either D9 virus or D9 tumor extract, but not by extract of an unrelated CELO virus-induced tumor. The virus and tumor extracts had little or no effect on the migration of peritoneal exudate cells from normal hamsters. Noninfectious D9 virus produces a cell-mediated immune response in the hamster and shares antigenicity with D9 lymphoma, which releases the virus.
机译:通过巨噬细胞迁移抑制试验测试了用非感染性C型仓鼠病毒(D9)或经辐照的D9肿瘤细胞免疫的仓鼠的细胞介导的免疫反应性。 D9病毒或D9肿瘤提取物可显着抑制免疫仓鼠腹膜分泌液的迁移,但无关的CELO病毒诱导的肿瘤提取物则不会。病毒和肿瘤提取物对正常仓鼠腹膜分泌液迁移的影响很小或没有影响。非感染性D9病毒在仓鼠中产生细胞介导的免疫反应,并与D9淋巴瘤具有抗原性,从而释放出该病毒。

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