Mitogen- and viral antigen-induced transformation of lymphocytes from normal mink and from mink with progressive or nonprogressive Aleutian disease.

S H An; B N Wilkie

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Mitogen- and viral antigen-induced transformation of lymphocytes from normal mink and from mink with progressive or nonprogressive Aleutian disease.

机译：正常水貂和进行性或非进行性阿留申病水貂的淋巴细胞由丝分裂原和病毒抗原诱导的淋巴细胞转化。

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Peripheral blood lymphocytes (PBL) from mink with progressive Aleutian disease (AD) were shown to be significantly less responsive to phytohemagglutinin, concanavalin A, and pokeweed mitogen than were PBL from normal mink and from mink with a nonprogressive form of AD. Response to the virus of AD was significantly greater in PBL cultures from mink with nonprogressive AD than in those from normal mink or mink with progressive AD. After experimental infection with AD virus, mink PBL were responsive to viral antigen only transiently. These findings suggest that lymphocyte responsiveness as indicated by transformation induced by mitogens or viral antigen may be an important aspect of host response to infection with the parvovirus of AD.

机译：已证明，进行性阿留申病（AD）的水貂的外周血淋巴细胞（PBL）对植物血凝素，伴刀豆球蛋白A和商陆有丝分裂原的反应显着低于正常水貂和非渐进形式水貂的PBL。在非渐进性AD的水貂中，PBL培养物中对AD病毒的反应明显大于正常水貂或渐进性AD的水貂中。在实验性感染AD病毒后，水貂PBL仅对病毒抗原短暂响应。这些发现表明，有丝分裂原或病毒抗原诱导的转化所表明的淋巴细胞反应性可能是宿主对AD细小病毒感染的反应的重要方面。

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《Infection and immunity》 |1981年第1期|共4页
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S H An; B N Wilkie;
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中图分类医学免疫学;
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1. Mitogen- and viral antigen-induced transformation of lymphocytes from normal mink and from mink with progressive or nonprogressive Aleutian disease. [J] . S H An, B N Wilkie Infection and immunity . 1981,第1期

机译：正常水貂和进行性或非进行性阿留申病水貂的淋巴细胞由丝分裂原和病毒抗原诱导的淋巴细胞转化。
2. Lymphocyte Abnormalities in Aleutian Disease Virus Infection of Mink: Decreased T Lymphocyte Responses and Increased B Lymphocyte Levels in Persistent Viral Infection [J] . Keith L. Banks, Lance E. Perryman, Travis C. McGuire The journal of immunology . 1975,第1期

机译：貂的阿留申病病毒感染中的淋巴细胞异常：持续性病毒感染中T淋巴细胞反应减少和B淋巴细胞水平增加
3. In situ molecular hybridization for detection of Aleutian mink disease parvovirus DNA by using strand-specific probes: identification of target cells for viral replication in cell cultures and in mink kits with virus-induced interstitial pneumonia. [J] . S Alexandersen, M E Bloom, J Wolfinbarger, Journal of Virology . 1987,第8期

机译：原位分子杂交用于通过使用链致探针检测阿列丁水貂病病毒DNA：鉴定细胞培养物中病毒复制的靶细胞和病毒诱导的间质性肺炎的病毒复制。
4. CELL MEDIATED IMMUNITY IN MINK WITH ALEUTIAN DISEASE. [D] . AN, SOO HWAN. 1979

机译：貂皮细胞介导的免疫性疾病。
5. Mitogen- and viral antigen-induced transformation of lymphocytes from normal mink and from mink with progressive or nonprogressive Aleutian disease. [O] . S H An, B N Wilkie 1981

机译：正常水貂和患有进行性或非进行性阿留申病水貂的淋巴细胞的丝裂原和病毒抗原诱导的淋巴细胞转化。
6. THE PATHOGENESIS OF ALEUTIAN DISEASE OF MINK : I. IN VIVO VIRAL REPLICATION AND THE HOST ANTIBODY RESPONSE TO VIRAL ANTIGEN [O] . Porter, David D., Larsen, Austin E., Porter, Helen G. 1969

机译：貂水肿的病因：I.体内病毒复制和对病毒抗原的宿主抗体反应

Mitogen- and viral antigen-induced transformation of lymphocytes from normal mink and from mink with progressive or nonprogressive Aleutian disease.

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