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首页> 外文期刊>Infection and immunity >Regulatory Interactions Between Macrophages and T-Cell Subsets in Listeria monocytogenes-Specific T-Cell Activation
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Regulatory Interactions Between Macrophages and T-Cell Subsets in Listeria monocytogenes-Specific T-Cell Activation

机译：李斯特菌特异性T细胞活化中巨噬细胞和T细胞亚群之间的调节相互作用

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Peritoneal exudate T lymphocytes from Listeria monocytogenes-immune mice in the presence of the homologous antigen (heat-killed L. monocytogenes) and normal macrophages showed L. monocytogenes-specific proliferative responses. Proliferation was inhibited by macrophages from L. monocytogenes- or Corynebacterium parvum-pretreated mice as well as by exogenous prostaglandin E2. Macrophage-dependent inhibition of T-cell proliferation—at least in part—could be reversed by addition of indomethacin. When selected L. monocytogenes-immune Lyt T-cell subsets were cultured in the presence of inhibitory macrophages, pretreatment with anti-Lyt 1 antiserum plus complement completely abrogated proliferation and pretreatment with anti-Lyt 2 and anti-Lyt 3 antisera plus complement markedly reduced proliferation. However, a mixture (1:1) of the two preselected Lyt T-cell subsets resulted in complete reconstitution of proliferative responses. In contrast, when L. monocytogenes-immune peritoneal exudate T lymphocytes were treated with anti-Lyt antisera plus complement after culture, only treatment with anti-Lyt 1 antiserum plus complement affected proliferation, suggesting regulatory interactions between Lyt 1+23? and Lyt 1?23+ T cells during in vitro culture which result in proliferation within the Lyt 1+23? T-cell subset. After rigorous depletion of residual macrophages and in the presence of indomethacin, pretreatment with anti-Lyt 1 antiserum plus complement, but not with anti-Lyt 2 and 3 antisera plus complement, eliminated proliferation. The data presented indicate that interactions between macrophages and Lyt T-cell subsets regulate L. monocytogenes-specific T-cell activation.
机译：在具有同源抗原（热灭活的单核细胞增生李斯特菌）的情况下，来自单核细胞增生李斯特菌免疫小鼠的腹膜分泌液T淋巴细胞和正常的巨噬细胞显示为 L。单核细胞增生特异性增殖反应来自 L的巨噬细胞抑制增殖。单核细胞增生-或小棒杆菌预处理的小鼠以及外源性前列腺素E 2 的小鼠。添加吲哚美辛可以逆转巨噬细胞对T细胞增殖的抑制（至少部分）。当选择了升。在抑制性巨噬细胞的存在下培养单核细胞增生因子免疫的Lyt T细胞亚群，用抗Lyt 1抗血清加补体完全消除增殖，用抗Lyt 2和抗Lyt 3抗血清加补体预处理明显减少增殖。但是，两个预选的Lyt T细胞亚群的混合物（1：1）导致增殖反应的完全重建。相反，当 L时。培养后，用抗Lyt抗血清加补体对单核细胞增生性抗体免疫腹膜渗出液T淋巴细胞进行处理，仅用抗Lyt 1抗血清加补体进行处理会影响增殖，提示Lyt 1 + 之间的调节相互作用23 ？和Lyt 1 ？ 23 + T细胞在体外培养期间会导致Lyt 1 + 23 ？ T细胞子集。残留巨噬细胞经过严格消耗后，在消炎痛存在下，用抗Lyt 1抗血清和补体进行预处理，但不使用抗Lyt 2和3抗血清和补体进行预处理，可以消除增殖。呈现的数据表明巨噬细胞和Lyt T细胞亚群之间的相互作用调节了L。单核细胞增生特异性T细胞活化

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