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Cell-produced viral inhibitor: possible mechanism of action and chemical composition.

机译:细胞产生的病毒抑制剂:可能的作用机理和化学组成。

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A newly recognized cell-produced viral inhibitor appeared to be spontaneously released from most cells in tissue culture. It strongly inhibited the replication of a variety of viruses but did not exhibit species specificity as does interferon. These studies on the inhibitor's mechanism of action indicated that it inhibited attachment and penetration of virus by a readily reversible reaction requiring the presence of both virus and cells. Studies of inactivation by specific enzymes or chemicals indicated that for activity the inhibitor required intact protein but not lipid, carbohydrate, deoxyribonucleic acid, or ribonucleic acid.
机译:新发现的细胞产生的病毒抑制剂似乎是从组织培养中的大多数细胞中自发释放的。它强烈抑制多种病毒的复制,但不像干扰素那样表现出物种特异性。这些对抑制剂作用机理的研究表明,它通过需要病毒和细胞同时存在的易于逆转的反应来抑制病毒的附着和渗透。通过特定酶或化学物质进行灭活的研究表明,为获得活性,抑制剂需要完整的蛋白质,但不需要脂质,碳水化合物,脱氧核糖核酸或核糖核酸。

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