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首页> 外文期刊>Infection and immunity >Stimulation of chemiluminescence by synthetic muramyl dipeptide and analogs.
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Stimulation of chemiluminescence by synthetic muramyl dipeptide and analogs.

机译：合成的穆拉米二肽和类似物刺激化学发光。

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摘要

The effect on respiratory burst of murine splenic cells after in vitro exposure to synthetic muramyl dipeptide (MDP) and 6-O-acyl and quinonyl derivatives was studied at an early phase of interaction by luminol-dependent chemiluminescence (CL) in response to stimulation by zymosan. The MDP molecule enhanced CL, but the degree of CL response varied with the kinds of fatty acids introduced in the chemical structure of synthetic glycopeptide analogs. A 6-O-acyl derivative possessing an alpha-branched fatty acid chain, B30-MDP, stimulated maximum levels of CL activity. High CL responses were obtained with L8-MDP having a short chain of linear fatty acids and with QS-10-MDP-66 containing a ubiquinone compound. CL was also stimulated by MDP and its analogs in the spleen cells of nude mice lacking mature T lymphocytes, but the extent of stimulation was decreased compared with that of normal spleen cells.
机译：在相互作用的早期阶段，通过鲁米诺依赖性化学发光（CL）响应由刺激引起的反应，研究了体外暴露于合成的穆拉米二肽（MDP）和6-O-酰基和奎尼酰基衍生物对鼠脾细胞呼吸爆发的影响。酵母聚糖。 MDP分子增强了CL，但CL反应的程度随合成糖肽类似物化学结构中引入的脂肪酸种类的不同而变化。具有α-支链脂肪酸链的6-O-酰基衍生物B30-MDP刺激了最大水平的CL活性。用具有直链脂肪酸短链的L8-MDP和含有泛醌化合物的QS-10-MDP-66获得高CL响应。 MDP及其类似物在缺乏成熟T淋巴细胞的裸鼠脾细胞中也刺激CL，但与正常脾细胞相比，其刺激程度有所降低。

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