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首页> 外文期刊>Infection and immunity >Bactericidal activity of alveolar and peritoneal macrophages exposed in vitro to three strains of Pasteurella multocida.
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Bactericidal activity of alveolar and peritoneal macrophages exposed in vitro to three strains of Pasteurella multocida.

机译：体外暴露于三株多杀巴斯德氏菌菌株的肺泡和腹膜巨噬细胞的杀菌活性。

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Normal ICR mice were infected intravenously, intraperitoneally, or aerogenically with Pasteurella multocida strains isolated from a turkey (S68), calf (V90), or rabbit (J20) lung. Both the turkey and calf isolates were highly virulent for mice and multiplied logarithmically in the lungs, liver, and spleen, resulting in death of the animals in 18 to 36 h. The rabbit strain was avirulent for mice, but repeated passage in mice did result in some increased virulence. All three strains of P. multocida were inactivated rapidly by normal mouse peritoneal macrophages, provided that the organisms were opsonized with specific hyperimmune serum before being exposed to the macrophage monolayers. P. multocida was slowly inactivated by normal mouse alveolar macrophages when the organisms were preopsonized. However, the surviving organisms later multiplied extensively in vitro. Macrophages harvested from hyperimmunized mice were no better at inactivating opsonized P. multocida cells than were normal mouse cells. The relative importance of the different phagocytic cell populations in the uptake and killing of opsonized P. multocida cells is discussed in relation to immunity to this important animal pathogen.
机译：用从火鸡（S68），小牛（V90）或家兔（J20）肺中分离出的多杀巴斯德氏菌菌株对静脉注射，腹膜内或造血感染正常的ICR小鼠。火鸡和小牛分离株对小鼠均具有高毒性，并且在肺，肝和脾中对数繁殖，导致动物在18至36小时内死亡。兔品系对小鼠无毒，但在小鼠中反复传代确实会导致某些毒力增加。正常小鼠腹膜巨噬细胞可迅速灭活这三株多杀疟原虫的菌株，但前提是该微生物应在暴露于巨噬细胞单层之前用特定的超免疫血清调理。当微生物被预先调理后，P。multocida被正常的小鼠肺泡巨噬细胞缓慢灭活。但是，幸存的生物随后在体外大量繁殖。从超免疫小鼠中收获的巨噬细胞在灭活调理过的多杀青霉菌细胞方面没有比正常小鼠细胞更好。讨论了不同吞噬细胞群在摄取和杀死调理的P. multocida细胞中的相对重要性，并与对该重要动物病原体的免疫力相关。

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