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首页> 外文期刊>Infection and immunity >Colonial dissociation and susceptibility to phagocytosis of Pseudomonas aeruginosa grown in a chamber implant model in mice.
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Colonial dissociation and susceptibility to phagocytosis of Pseudomonas aeruginosa grown in a chamber implant model in mice.

机译：在小鼠腔室植入模型中生长的铜绿假单胞菌的菌落解离和对吞噬作用的敏感性。

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Pseudomonas aeruginosa strains were grown in 1-cm plastic chambers sealed at both ends with porous Millipore filters and implanted in the peritonea of mice. Mucoid and nonmucoid strains of P. aeruginosa isolated from a patient with cystic fibrosis largely retained their phenotypes when grown for up to 1 year in this in vivo system, although colonial dissociation occurred, as observed in chronic lung infections of patients with cystic fibrosis. In the absence of added opsonins, P. aeruginosa M2 cells taken directly from the in vivo system were significantly more susceptible to phagocytosis than were the same P. aeruginosa cells after being washed in buffer. Phagocytosis of in vivo-grown P. aeruginosa cells could be further enhanced by using a porin protein F-specific monoclonal antibody.
机译：铜绿假单胞菌菌株在两端用多孔密理博滤器密封的1厘米塑料室内生长，并植入小鼠腹膜中。从囊性纤维化患者分离的铜绿假单胞菌的粘液和非粘液菌株在该体内系统中生长长达1年后，在很大程度上保留了它们的表型，尽管发生了结肠分离，如在囊性纤维化患者的慢性肺部感染中观察到的。在没有添加调理素的情况下，直接从体内系统提取的铜绿假单胞菌M2细胞比相同的铜绿假单胞菌细胞在缓冲液中洗涤后更容易吞噬。体内生长的铜绿假单胞菌细胞的吞噬作用可以通过使用孔蛋白F特异性单克隆抗体来进一步增强。

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