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Protection of mice against Listeria monocytogenes infection by recombinant human tumor necrosis factor alpha.

机译:通过重组人肿瘤坏死因子α保护小鼠抵抗单核细胞增生李斯特菌感染。

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摘要

Recombinant human tumor necrosis factor alpha (rHuTNF-alpha) administered intravenously to mice resulted in enhanced resistance to a lethal challenge infection of Listeria monocytogenes given 24 h later. The observed protection was lost following treatment of the rHuTNF-alpha preparations with rabbit polyclonal antibody rHuTNF-alpha but not with normal rabbit immunoglobulin G.
机译:静脉内给予小鼠的重组人肿瘤坏死因子α(rHuTNF-α)导致对24小时后给予的单核细胞增生性李斯特菌致死性攻击的抵抗力增强。用兔多克隆抗体rHuTNF-alpha处理rHuTNF-alpha制剂后,但未用正常兔免疫球蛋白G处理后,观察到的保护作用消失了。

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