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首页> 外文期刊>Infection and immunity >Use of DBA/2N mice in models of systemic candidiasis and pulmonary and systemic aspergillosis.
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Use of DBA/2N mice in models of systemic candidiasis and pulmonary and systemic aspergillosis.

机译：DBA / 2N小鼠在系统性念珠菌病以及肺和全身曲霉病模型中的用途。

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摘要

Mouse models of systemic candidiasis and pulmonary and systemic aspergillosis were established by using DBA/2N mice, which are known to be deficient in the C5 component of complement. In experiments comparing lethality in the respective models in DBA/2N versus outbred CFW mice, results showed that the 50% lethal dose values for the DBA/2N mice were 10- to 1,000-fold lower than those for the outbred mice, depending on the experiment. Additionally, onset of death was somewhat delayed for the DBA/2N mice. In the case of the pulmonary aspergillosis model, administration of cortisone acetate was necessary to ensure lethality after intranasal infection, but only a single dose was necessary.
机译：使用DBA / 2N小鼠建立了系统性念珠菌病，肺和全身曲霉病的小鼠模型，已知它们的补体C5成分不足。在比较DBA / 2N和远距离CFW小鼠各自模型中的致死率的实验中，结果表明，DBA / 2N小鼠的50％致死剂量值比远距离小鼠的致死剂量低10-1,000倍，具体取决于实验。此外，DBA / 2N小鼠的死亡发作有所延迟。对于肺曲霉病模型，必须给予醋酸可的松以确保鼻内感染后的致死性，但仅需单剂。

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