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首页> 外文期刊>Infection and immunity >Clinical correlates of in vitro Plasmodium falciparum cytoadherence.
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Clinical correlates of in vitro Plasmodium falciparum cytoadherence.

机译：体外恶性疟原虫细胞粘附的临床相关性。

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摘要

To determine whether isolates of Plasmodium falciparum have intrinsically different cytoadherent properties and whether these differences contribute to the clinical severity of human falciparum malaria, we studied the cytoadherence to C32 melanoma cells in vitro of 59 parasite isolates from patients with naturally acquired infections in Thailand. Parasitized erythrocytes adhere to these melanoma cells principally via the glycoprotein CD36, which is also expressed on most vascular endothelium. In vitro cytoadherence was significantly greater for isolates from patients with biochemical evidence of severe malaria. The cytoadherent properties of P. falciparum parasites may thus be a virulence factor in human falciparum malaria. However, there was no correlation between the degree of in vitro cytoadherence and cerebral symptoms, which suggests that other receptors and/or host factors may be important in the adherence of malaria parasites to cerebral vascular endothelium. The cytokines tumor necrosis factor, interleukin-1, and gamma interferon, which have been implicated in the pathogenesis of cerebral malaria and are known to promote intercellular adhesion in other systems, did not enhance the cytoadherence of P. falciparum isolates to C32 melanoma cells.
机译：为了确定恶性疟原虫的分离株是否具有本质上不同的细胞粘附特性，以及这些差异是否导致人恶性疟疾的临床严重性，我们在泰国研究了59种来自自然感染的寄生虫分离株对C32黑色素瘤细胞的体外细胞粘附性。寄生的红细胞主要通过糖蛋白CD36粘附在这些黑色素瘤细胞上，糖蛋白CD36在大多数血管内皮细胞中也表达。从具有严重疟疾生化证据的患者中分离出的细菌，其体外细胞粘附性明显更高。因此，恶性疟原虫寄生虫的细胞粘附特性可能是人恶性疟疾中的一种毒力因子。但是，体外细胞粘附程度与脑部症状之间没有相关性，这表明其他受体和/或宿主因素可能在疟原虫与脑血管内皮的粘附中很重要。细胞因子肿瘤坏死因子，白介素-1和γ干扰素已与脑疟疾的发病机制有关，并已知在其他系统中促进细胞间粘附，但并未增强恶性疟原虫分离株对C32黑色素瘤细胞的细胞粘附性。

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