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首页> 外文期刊>Infection and immunity >Sodium dodecyl sulfate- and salt-extracted antigens from various Brucella species induce proliferation of bovine lymphocytes.
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Sodium dodecyl sulfate- and salt-extracted antigens from various Brucella species induce proliferation of bovine lymphocytes.

机译：来自各种布鲁氏菌属物种的十二烷基硫酸钠和盐提取的抗原诱导牛淋巴细胞的增殖。

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摘要

One- and two-dimensional gel electrophoresis and cellular immunoblotting were used to compare the protein profiles and immunogenic capabilities of salt- and sodium dodecyl sulfate-extracted components isolated from different Brucella species. Cellular immunoblotting demonstrated that freshly isolated bovine peripheral blood mononuclear cells proliferated to similar molecular mass components from the various Brucella extractions. One- and two-dimensional gel electrophoresis showed similarities in protein profiles among the different Brucella species that correlated with lymphocyte reactivity. The results presented in this study provide preliminary evidence that common proteins that induce lymphocyte proliferation are present among different Brucella species, suggesting that a genuswide subunit vaccine may be feasible.
机译：使用一维和二维凝胶电泳以及细胞免疫印迹来比较分离自不同布鲁氏菌属物种的盐和十二烷基硫酸钠提取的组分的蛋白质谱和免疫原性。细胞免疫印迹表明，新鲜分离的牛外周血单核细胞从各种布鲁氏菌提取物中增殖为相似的分子量成分。一维和二维凝胶电泳显示不同布鲁氏菌物种之间的蛋白质谱具有相似性，这与淋巴细胞反应性相关。这项研究中提供的结果提供了初步的证据，即在不同的布鲁氏菌物种之间存在诱导淋巴细胞增殖的常见蛋白质，这表明全属亚单位疫苗可能是可行的。

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