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首页> 外文期刊>Infection and immunity >Relationship between bactericidal action of complement and fluidity of cellular membranes.
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Relationship between bactericidal action of complement and fluidity of cellular membranes.

机译：补体的杀菌作用与细胞膜流动性之间的关系。

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摘要

The mode of complement-mediated killing of Escherichia coli B cells grown at 25 and 42 degrees C and of E. coli K-12 UFAts cells grown in the presence of oleic and elaidic aicds was examined in relation to their membrane lipid compositions and the thermodynamic properties of membrane phospholipids. Phospholipids isolated from 25 degrees C-grown cells of strain B and from oleic acid-incorporated cells of strain K-12 UFAts had lower phase transition temperatures than did phospholipids from E. coli strain B grown at 42 degrees C or those from strain K-12 UFAts grown on elaidic acid. The rate of cellular susceptibility to complement action closely correlated with the liquid crystalline phase of phospholipids of cell membranes. These findings suggest that membrane fluidity is obligatory for the final expression of complement action.
机译：考察了补体介导的在25和42摄氏度下生长的E.coli B细胞和在油酸和油酸存在下生长的E.coli K-12 UFAts细胞的膜脂质组成和热力学关系膜磷脂的性质。从在25摄氏度生长的B株细胞和从油酸结合的K-12 UFAts细胞分离的磷脂的相变温度低于在42摄氏度下生长的E.coli菌株B或从K-菌株获得的磷脂的相变温度。在尤里酸上生长的12种UFA。细胞对补体作用的敏感性与细胞膜磷脂的液晶相密切相关。这些发现表明膜的流动性对于补体作用的最终表达是必需的。

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