Interferon treatment of NZB mice: accelerated progression of autoimmune disease.

H Heremans; A Billiau; A Colombatti; J Hilgers; P de Somer

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Interferon treatment of NZB mice: accelerated progression of autoimmune disease.

机译：NZB小鼠的干扰素治疗：加速自身免疫性疾病的进展。

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The effect of long-term administration of interferon in New Zealand Black and New Zealand Black/New Zealand White F1 hybrid mice was studied. Treatment with moderate doses of interferon (10(4) units, five times weekly for 8 weeks) did not depress murine leukemia virus gp69/71 levels in serum and spleen, nor p30 levels in the spleen. Interferon given at 10(5.1) units (three times weekly for 37 weeks) caused an increased incidence of anti-erythrocyte antibodies in New Zealand Black mice. Finally, the hybrid mice given interferon at 10(6.0) units (three times weekly for 33 weeks) had increased renal immune complex deposits and increased incidences of proteinuria and anemia.

机译：研究了长期施用干扰素对新西兰黑和新西兰黑/新西兰白F1杂种小鼠的影响。用中等剂量的干扰素（10（4）单位，每周五次，共8周）治疗不会降低鼠白血病病毒的血清和脾脏gp69 / 71水平，也不会降低脾脏p30水平。剂量为10（5.1）单位的干扰素（每周3次，共37周）导致新西兰黑小鼠中抗红细胞抗体的发生率增加。最后，以10（6.0）单位（每周3次，共33周）给予干扰素的杂种小鼠，其肾脏免疫复合物沉积增加，蛋白尿和贫血的发生率也增加。

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《Infection and immunity》 |1978年第3期|共6页
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H Heremans; A Billiau; A Colombatti; J Hilgers; P de Somer;
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中图分类医学免疫学;
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1. Alteration of the spontaneous systemic autoimmune disease in (NZB x NZW)F1 mice by treatment with thimerosal (ethyl mercury). [J] . Havarinasab S, Hultman P Toxicology and Applied Pharmacology . 2006,第1期

机译：硫柳汞（乙基汞）处理可改变（NZB x NZW）F1小鼠的自发性全身自身免疫疾病。
2. Spontaneous autoimmune disease in (NZB x NZW)F1 mice is ameliorated by treatment with methimazole. [J] . Mozes E, Zinger H, Kohn LD, Journal of Clinical Immunology . 1998,第2期

机译：甲巯咪唑治疗可减轻（NZB x NZW）F1小鼠的自发性自身免疫疾病。
3. Spontaneous autoimmune disease in (NZB x NZW)F1 mice is ameliorated by treatment with methimazole. [J] . Mozes E, Zinger H, Kohn LD, Journal of Clinical Immunology . 1998,第2期

机译：甲巯咪唑治疗可减轻（NZB x NZW）F1小鼠的自发性自身免疫疾病。
4. Prevalence of autoantibodies and the risk of autoimmune thyroid disease in children with chronic hepatitis C virus (HCV) infection treated with alpha-interferon [C] . S. GEHRING, E. LAUSCH, U. KULLMER, Falk Symposium . 2002

机译：α-干扰素治疗慢性丙型肝炎病毒（HCV）感染儿童自身抗体和自身免疫性甲状腺疾病风险的患病率
5. The absence of CD62L (L-selectin) does not inhibit the progression of autoimmune diabetes in nonobese diabetic (NOD) mice. [D] . Friedline, Randall Henry. 2001

机译：在非肥胖糖尿病（NOD）小鼠中，CD62L（L-选择素）的缺乏不会抑制自身免疫性糖尿病的进展。
6. Interferon treatment of NZB mice: accelerated progression of autoimmune disease. [O] . H Heremans, A Billiau, A Colombatti, 1978

机译：NZB小鼠的干扰素治疗：加速自身免疫性疾病的进展。
7. Pristane-Accelerated Autoimmune Disease in (SWR X NZB) F1 Mice Leads to Prominent Tubulointerstitial Inflammation and Human Lupus Nephritis-Like Fibrosis. [O] . Agnes Gardet, Wei C Chou, Taylor L Reynolds, 2016

机译：（sWR X NZB）F1小鼠中的降植烷加速自身免疫疾病导致突出的肾小管间质炎症和人类狼疮肾炎样纤维化。

Interferon treatment of NZB mice: accelerated progression of autoimmune disease.

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