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首页> 外文期刊>Infection and immunity >Cryoglobulins, circulating immune complexes, and complement activation in cerebral malaria.
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Cryoglobulins, circulating immune complexes, and complement activation in cerebral malaria.

机译：冰冻球蛋白，循环免疫复合物和脑疟疾中的补体激活。

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A total of 32 patients with Plasmodium falciparum malaria were studied. Of these, 23 had benign infections, and 9 had typical cerebral malaria. Cryoglobulins, circulating immune complexes detected by a C1q-binding assay, and hypocomplementemia were found in eight of nine patients with cerebral malaria. Raised levels of complement component 3 breakdown products (C3d) were found in the seven patients tested. Peak levels of circulating immune complexes and C3d were associated with thrombocytopenia. In contrast, in patients with benign Plasmodium falciparum malaria, cryoglobulins and circulating immune complexes were found only in 3 of 23 patients. Similarly, hypocomplementemia was detected only in 5 of 23 patients. These observations suggest that the intensity of the immune response and of the associated complement activation may be important factors in the pathogenesis of cerebral malaria.
机译：共研究了32例恶性疟原虫疟疾患者。其中，23例为良性感染，9例为典型的脑疟疾。在9例脑疟疾患者中，有8例发现了球蛋白，C1q结合测定法检测到的循环免疫复合物和低补体血症。在测试的七名患者中发现补体成分3分解产物（C3d）的水平升高。循环免疫复合物和C3d的峰值水平与血小板减少有关。相反，在恶性疟原虫疟疾患者中，仅23例患者中有3例发现冷球蛋白和循环免疫复合物。同样，仅在23名患者中的5名患者中发现了补体不足。这些观察结果表明，免疫应答和相关补体激活的强度可能是脑疟疾发病机理中的重要因素。

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